
Hello ,
Last week a patent (#7,524,500) was issued covering the crosslinking of CD163 as a method of activating stem cells. CD163 is a scavenger receptor primarily known for its expression on macrophages.
Another relevant patent from last week was #7,524,490 which covers the use of clusterin transfected bone marrow stem cells for suppressing apoptosis in the heart. Clusterin is a protein involved in control of cell death and cell communications.
In the news, a paper was published describing rejection of allogeneic embryonic stem cell derived dopaminergic cells in an allogeneic system.
Methods of expanding stem cells are well-known in the art. For example, #7,423,029 teaches the use of heterocyclic trialkyl ammonium-containing compounds for stimulation of bone marrow stem cells. #7,135,459 covers use of FGF homologues for expansion of neural and... Nara, Japan - Seeing stem cell therapy as sources of cytokines or angiogenic factors allows the possibility that the stem cell will eventually be rejected but the therapeutic effect will remain. For example, mesenchymal stem cells are known to secrete various immune modulatory factors, such as soluble Ask a question OR leave your comments.
Method of stimulating stem cells
Allogeneic rejection of embryonic stem cells
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