Human pancreatic epithelial progenitor cells and methods of isolation and use thereof

This patent deals with the problem that the majority of pancreatic progenitor cells known at the time of filing are only capable of differentiating into islets but not other cells in the pancreas. Specifically, the patent cites patents 5,888,705 (Compositions and method of stimulating the proliferation and differentiation of human fetal and adult pancreatic cells ex vivo) and 5,834,308 (In...

Human ovarian mesothelial cells and methods of isolation and uses thereof

This patent covers a new type of ovarian progenitor cell. Specifically, the patent has 1 independent claim covering a cell population that can differentiate into overian epithelium or granulosa cells. Two other claims that appear to be of high importance are the use of this cell for production of proteins, and the use of this cell for bioassays.

Genetically altered mammalian embryonic stem cells, their living progeny, and their therapeutic application for improving cardiac function after myocardial infarction

This patent covers the use of embryonic stem cells as a source of stem cells for myocardial regeneration. Specifically, this patent covers genetically manipulated cells that are useful for these purposes.

Isolation and use of solid tumor stem cells

The cancer stem cell is very important since there is numerous investigators in the field that believe the majority of cancer cells making up a tumor mass are only the products of a specific cell subpopulation with high repopulating potential. What this means is that usually the drugs developed for cancer are developed to kill not the stem cell of the tumor, but actually the progeny of the...

Adult human dental pulp stem cells in vitro and in vivo

This patent covers a new type of stem cell derived from the dental pulp, it is useful for entities seeking to generate articial teeth, or dendin/pulp tissue. However, given that the patent actually claims a tooth stem cell, it may also be considered a composition of matter patent (although phenotype is somewhat ill defined in the claims). The patent has 3 independent claims. The first covers...

Date of First Priority Issue: Friday July 21st, 2000 1 Comment

Pancreatic progenitor 1 gene and its uses

PP1 is a protein marker of a type of tissue stem cells or progenitor cells. The PP1 protein is made of 221 amino acids and contains two cysteine-rich domains. PP1 is expressed in the ducts of the regenerating pancreas in regions where new islets are developing. In addition, PP1 is expressed...

Human ovarian mesothelial cells and methods of isolation and uses thereof

This paper teaches the isolation of bi-potent overian stem cells that can differentiate either into overian epithelium, or granulosa cells. The cell type claimed can be used for many purposes, including: a) generation of antibodies; b) cell therapy; c) bioassays; d) drug screening. The patent has two independent claims that cover: A method of isolating a substantially pure population...

Human pancreatic epithelial progenitor cells and methods of isolation and use thereof

This patent covers a type of pancreatic stem cell that can be grown and expanded outside of the body. The cells are defined as expressing the following markers: cytokeratin-19, CEA, carbonic anhydrase II, and CFTCR.