Patents (1436 Stem Cell Patents)

Class: Type (195)

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Clonal cultures of primate embryonic stem cells

Patent Number: 7,217,569

This patent covers ways to generate "clonal" embryonic stem cell lines. At face value this specification does not seem to offer anything new in comparison to the previous WARF patents.

Inventors: Thomson; James A (Madison, WI)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Thursday March 9th, 2000

Isolation and use of solid tumor stem cells

Patent Number: 6984522

In the cancer patient it is believed that tumors are actually a heterogeneous population of cells, and that not all the tumor cells have equal proliferative capability. This concept of the "tumor stem cell" maintaining the bulk of the tumor population is very important since many believe that the cells targeted by conventional therapies are not the actual tumor stem cell but derivatives...

Inventors: Clarke, Michael F. (Ann Arbor, MI); Morrison, Sean J. (Ann Arbor, MI); Wicha, Max S. (Ann Arbor, MI); Al-Hajj, Muhammad (Ann Arbor, MI)
Assignee: Regents of the University of Michigan (Ann Arbor, MI)
Date of First Priority Issue: Wednesday March 8th, 2000

Adipose tissue-derived stromal cell that expresses characteristics of a neuronal cell

Patent Number: 7078230

This patent is useful for entities interested in neurodegeneration and sources of neural-like cells. The patent is a composition of matter patent on adipose tissue derived cells that are endowed with neural characteristics. The patent has 2 independent claims, the first covers an adipose tissue derived stromal cell that is differentiated to express neuronal phenotypic markers. The second...

Inventors: Wilkison, William O. (Bahama, NC); Gimble, Jeffrey (Chapel Hill, NC)
Assignee: Artecel, Inc. (Baltimore, MD)
Date of First Priority Issue: Saturday February 26th, 2000

Tooth progenitor cell and method for its production

Patent Number: 7,498,168

This patent covers methods of producing tooth progenitor cells from either neural stem cells or embryonic stem cells.  The process covers contacting the stem cell with cells derived from the oral epithelium so as to induce expression of the genes Barx-1 and Dlx-5.

Essentially this patent is teaching markers associated with the process of differentiation, as well as progenitor...

Inventors: Sharpe; Paul Thomas (London, GB)
Assignee: Odontis Limited (London, GB)
Date of First Priority Issue: Friday February 18th, 2000

Isolation and transplantation of retinal stem cells

Patent Number: 7,514,259

This patent uses claim language associated with method of use, but is actually teaching what appears to be a new type of retinal stem cell.  The first independent claim reads:

"A method of repopulating photoreceptor cells of a mammal, said method comprising the steps of: providing neuroretina-derived retinal stem cells obtained from a neurosphere from a mammalian donor...

Inventor: Isolation and transplantation of retinal stem cells
Assignee: Young Michael J. (Gloucester, MA); Klassen Henry J. (Pasadena, CA); Shatos Marie A. (Athol, MA); Mizumoto Keiko (Higashi, JP)
Date of First Priority Issue: Friday February 11th, 2000

Compositions and methods for generating skin

Patent Number: 7,560,275

This patent covers a mammalian cell that has properties of spores and is useful for regeneration of new skin. 

Its first independent claim is:

A population of isolated mammalian or avian multipotent spore-like cells (MSLCs) isolated or cultured from skin tissue and which can differentiate into two or more mature skin cell type cells. wherein the MSLCs, when first isolated, are...

Inventors: Vacanti; Martin P. (Westborough, MA), Vacanti; Charles A. (Uxbridge, MA)
Assignee: VBI Technologies, L.L.C. (Houston, TX)
Date of First Priority Issue: Thursday December 30th, 1999

Immortalized human stromal cell lines

Patent Number: 6541249

This patent covers some stromal cell lines that have been deposited with ATCC. These cell lines are useful for expansion of hematopoietic stem cells since they secrete a variety of different cytokines. I would be interesting to see if they support expansion of other types of stem cells such as neuronal stem cells.

Inventors: Wager, Ruth E. (Rockville, MD); Ourmanova, Maria (Boyds, MD)
Assignee: Human Genome Sciences, Inc. (Rockville, MD)
Date of First Priority Issue: Wednesday December 22nd, 1999

Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations

Patent Number: 7037719

This patent teaches how to isolate neuronal stem cells from human fetal brain. The stem cells, or I guess more appropriately, "progenitor cells", are isolated based on positive expression of AC133, binding to the antibody 5E12 (don’t know what that is), and negative for CD34 and CD45. The patent has 6...

Inventors: Buck, David W. (Heathfield, GB); Uchida, Nobuko (Palo Alto, CA); Weissman, Irving (Redwood City, CA) )
Assignee: StemCells California, Inc. (Palo Alto, CA
Date of First Priority Issue: Thursday December 2nd, 1999

Cultures of GFAP nestin cells that differentiate to neurons

Patent Number: 7,303,912

This patent covers, in its broadest issued claim, a type of stem cell that is useful for the generation of neurons. The cell population covered is a culture of cells expressing glial fibrillary acidic protein and nestin. In some dependent claims the cells may be extracted from the medial ganglionic eminence (MGE) and lateral ganglionic eminence (LGE). This patent is useful if the...

Inventors: Wahlberg; Lars (Asnaes, DK), Campbell; Kenneth (Cincinnati, OH), Skogh; Charlotta (Malmo, SE), Eriksson; Cecilia (Falsterbo, SE), Wictorin; Klas (Lund, SE)
Assignee: NsGene A/S (Ballerup, DK)
Date of First Priority Issue: Monday October 25th, 1999

Suppressor cells induced by culture with mesenchymal stem cells for treatment of immune responses in transplantation

Patent Number: 6685936

In an effort to solidify its IP wall, Osiris decided not only to cover immune suppression by mesenchymal stem cells, but also the ability of mesenchymal stem cells to elicit other immunosuppressive cells. In this patent to ability of mesenchymal stem cells to activate/expand suppressor T cells, and other types of immune suppressor cells is covered.

Inventors: McIntosh, Kevin (Ellicott City, MD); Klyushnenkova, Elena (Baltimore, MD)
Assignee: Osiris Therapeutics, Inc. (Baltimore, MD)
Date of First Priority Issue: Tuesday October 12th, 1999

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