Telemerase is critical for maintain telomere length and preventing senescence once cells have reached the Hayflick limit. This patent teaches the use of transfection with telomerase reverse transcriptase in order to generate neural progenitors that are immortal. The patent covers a wide variety of neural progenitors and sources of neural progenitors, including, dopaminergic, cholinergic...
This is a patent covering an ovarian stem cell that can become either overian epithelial tissue, as well as granulosa tissue. The three independent claims are: A method of providing a source of immunogen to a heterologous recipient, comprising administering a plurality of ovarian mesothelial cells in an amount effective to induce an immune response in said recipient...
This is a composition of matter patent on a type of bone marrow derived stem cell. The authors state that marrow stromal cells (MSCS) are adult stem cells from bone marrow that can differentiate into multiple non-hematopoietic cell lineages. The authors identified that colonies of human MSCs contain both small, rapidly self-renewing stem cells (RS cells) and large...
This patent covers methods of using a type of fetal stem cell in experimental systems or in humans. It seems to be a clever claiming strategy.
Essentially the patent claims a method for transplanting an isolated population of human neuroepithelial precursor cells into an animal comprising: (a) isolating human neuroepithelial precursor cells from human fetal tissue by a method...
This patent covers methods of generating transgenic animals through the use of donor cells that express the telomerase reverse transcriptase. The expression of telomerase in the donor cell apparently increases the efficacy of cloning. There are 4 independent claims in the patent, all covering "a method for generating transgenic non-primate mammals by nuclear transfer", and all...
This is a composition of matter patent for mesenchymal stem cell progenitors. The first three independent claims of this patent are restricted to generation of these cells from a Dexter type culture system (a specific type of long term culture in which adherent cells are allowed to form a layer and the hematopoietic cells rely on their support). The forth independent claim is not restricted...
This patent covers a method for producing a pigment epithelial cell of the eye through in vivo transfection of therapeutic genes such as neurotrophic factors, antiangiogenic factors, antioxidative factors, lysosomal factors, and/or vasodilating factors.
This patent covers a renal stem cell that is identified based on expression of the markers flk-1 and Sca-1. It is interesting how some many stem cells of different tissues all express similar markers and in some situations similar properties. Examples of such similarities include expression of Sca-1 (which appropriately stands for "stem cell antigen") on stem cells ranging from...
This patent covers a mesenchymal-like stem cell obtained by first flushing a placenta so that cord blood is substantially cleared, and subsequently perfusing the placenta to collect cells that are CD34 negative and have stem cell properties.
The cell type covered appears to be: positive for one or more of the following markers: SH2, SH3, SH4...