Patents
Mobilization of hematopoietic cells
Patent Number: 7,417,026Mobilization of stem cells is a very hot area these days. At face value, mobilization is important for donors of hematopoietic stem cells since it alleviates the need for performing puncture of the iliac crest of healthy people who are donating bone marrow. Currently, mobilization is performed by administering to the donor G-CSF (neupogen), which activates a cascade of enzymes and...
Inventors: Williams; David A. (Cincinnati, OH), Zheng; Yi (Cincinnati, OH)
Assignee: Children's Hospital Medical Center (Cincinnati, OH)
Date of First Priority Issue: Wednesday August 13th, 2003
Feeder-free culture method for embryonic stem cells or primate primordial stem cells
Patent Number: 7,413,902This patent covers the expansion of embryonic stem cells (referred to in the patent as primate primordial stem cells) by growing them in a media that lacks feeder cells but has the extracellular matrix of lysed fibroblast cells. It also covers growth of embryonic stem cells in extracellular matrix combined with agents such as FGF, forskolin, and various nutrients. The point of the...
Inventors: Bodnar; Andrea G. (Oshawa, CA), Chiu; Choy-Pik (Cupertino, CA), Gold; Joseph D. (San Francisco, CA), Inokuma; Margaret (San Jose, CA), Murai; James T. (San Bruno, CA), West; Michael D. (Boston, MA)
Assignee: Geron Corporation (Menlo Park, CA)
Date of First Priority Issue: Thursday October 23rd, 1997
Treatment of retinitis pigmentosa with human umbilical cord cells
Patent Number: 7,413,734Classically cord blood transplantation is used for the treatment of hematological disorders in which the recipient hematopoietic stem cell compartment is ablated (by chemotherapy and/or radiation) and the donor cord blood cells are used for hematopoietic rescue. However the use of cord blood in the area of regenerative medicine (non-hematopoietic purposes) does not require destruction of the...
Inventors: Mistry; Sanjay (Bedminster, NJ), Messina; Darin J. (Somerville, NJ), Harris; Ian Ross (Belle Mead, NJ), Harmon; Alexander M. (Clinton, NJ), Seyda; Agnieszka (New Brunswick, NJ), Yi; Chin-Feng (Hillsborough, NJ), Gosiewska; Anna (Skillman, NJ)
Assignee: Ethicon, Incorporated (Somerville, NJ)
Date of First Priority Issue: Friday June 27th, 2003
Methods of regulating differentiation in stem cells
Patent Number: 7,413,903This patent covers the use of agonists of LPL receptors to inhibit differentiation of embryonic stem cells. The inhibition of embryonic stem cell differentiation is important since the innate tendency of these cells is to differentiate when grown in absence of specific feeder cells and cytokines. While companies such as Geron have patents on specific culture systems that inhibit...
Inventors: Pebay; Alice Marie (Melbourne, AU), Pera; Martin Frederick (Prahran, AU)
Assignee: ES Cell International PTE Ltd. (Victoria, AU)
Date of First Priority Issue: Friday June 6th, 2003
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Human embryonic stem cells having genetic modifications
Patent Number: 7,413,904This patent covers a method of generating human embryonic stem cells that are genetically modified. Specifically, it claims the methodology of: obtaining a human embryonic stem cells that are in absence of feeder cells but kept viable in an extracellular matrix composition with media conditioned by fibroblasts, inserting into the cells a polynucleotide, and maintaining the cells in an...
Inventors: Gold; Joseph D. (San Francisco, CA), Carpenter; Melissa K. (London, CA), Inokuma; Margaret S. (San Jose, CA), Xu; Chunhui (Palo Alto, CA)
Assignee: Geron Corporation (Menlo Park, CA)
Date of First Priority Issue: Thursday October 23rd, 1997
Primitive and proximal hepatic stem cells
Patent Number: 7,413,897The liver is one of the organs that has been demonstrated to respond to stem cell therapy both in animal models and in clinical trials. It is known that the liver has endogenous stem cells, but also that bone marrow stem cells can differentiate into liver cells. In fact, it is published that bone...
Inventors: Reid; Lola M. (Chapel Hill, NC), Moss; Nicholas (Carrboro, NC), Furth; Mark (Chapel Hill, NC), Ludlow; John W. (Carrboro, NC), Bruce; Andrew T. (Holly Springs, NC)
Assignee: University of North Carolina at Chapel Hill (Chapel Hill, NC); Vesta Therapeutics, Inc. (Bethesda, MD)
Date of First Priority Issue: Thursday August 14th, 2003
Culture system for rapid expansion of human embryonic stem cells
Patent Number: 7,410,798This patent covers methods of expanding embryonic stem cells in vitro in large quantities without inducing their differentiation. Essentially the method covered is represented by the first independent claim which discloses the culture system which contains an extracellular matrix, a non-conditioned medium, and 40 nanograms per ml of FGF. The claim also states that the culture is free...
Inventors: Mandalam; Ramkumar (Union City, CA), Xu; Chunhui (Cupertino, CA), Gold; Joseph D. (San Francisco, CA), Carpenter; Melissa K. (Castro Valley, CA)
Assignee: Geron Corporation (Menlo Park, CA)
Date of First Priority Issue: Wednesday September 5th, 2001
Method of preparing an undifferentiated cell
Patent Number: 7,410,773This patent is either way ahead of its time, or there are some problems in its commercialization. The patent covers a method of "dedifferentiating" mature cells in order to an immature phenotype or to increase the ability of the cells to act like stem cells. The first claim of the patent covers a means of augmenting the number of cells expressing a stem cell marker(s) in a...
Inventors: Abuljadayel; Ilham Saleh (London, GB)
Assignee: Ghazi Jaswinder Dhoot (London, DE)
Date of First Priority Issue: Thursday February 2nd, 1995
Meningeal-derived stem cells
Patent Number: 7,410,797The current patent covers a type of multipotent stem cell derived from the meninges. This is the three layered membrane that surrounds the cerebrospinal fluid and central nervous system. The inventors have demonstrated that cells isolated from this membrane, regardless of whether they are from the dura mater, pia mater, or arachnoid mater, can be substantially expanded in vitro and...
Inventors: Ogle; Roy C. (Earlysville, VA), Tholpady; Sunil (Charlottesville, VA)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Tuesday June 11th, 2002
Kits for treatment of hematologic disorders
Patent Number: 7,408,039Hematopoietic stem cell transplantation has saved many lives of patients with hematological and metabolic malignancies. Unfortunately, one of the major side effects of this treatment is graft versus host. The company Osiris is in advanced stages of clinical trials (Phase III) using mesenchymal stem cells to treat this condition in which lymphocytes from the donor start attacking the...
Inventors: Sykes; Megan (Boston, MA), Spitzer; Thomas R. (Andover, MA)
Assignee: The General Hospital Corporation (Boston, MA)
Date of First Priority Issue: Friday November 14th, 1997