Patents
Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations
Patent Number: 7,381,561This patent covers methods of isolating neural stem cells using antibodies that bind CD49f. The first independent claim is very broad in that it is not restricted to originating material of adult or embryonic origin but simply covers a method of purifying a population by selecting for cells that initiate neurospheres in culture and express CD49f. CD49f is found on other types of stem cells as...
Inventors: Uchida; Nobuko (Palo Alto, CA), Capela; Alexandra (Mountain View, CA)
Assignee: StemCells California, Inc. (Palo Alto, CA)
Date of First Priority Issue: Tuesday August 27th, 2002
Transgenic pigs carrying both hHO-1 and hDAF transgenes for xenotransplantation
Patent Number: 7,378,569Xenotransplantation offers the possibility of using animal organs either permanently as a substitute for human organs, or as a "bridge" until a suitable human organ may be found. The most significant barriers to xenotransplantation appear to be innate in nature. Specifically, the first barrier is the hyperacute rejection, which occurs because of a very high level of preformed...
Inventors: Tu; Ching-Fu (Miaoli Hsien, TW), Yang; Chi-Kai (Miaoli Hsien, TW), Liu; Ming-Shing (Miaoli Hsien, TW), Ho; Lin-Lin (Miaoli Hsien, TW), Huang; Kuei-Feng (Miaoli Hsien, TW), Lee; Chun-Jean (Miaoli Hsien, TW), Tai; Hao-Chih (Miaoli Hsien, TW)
Assignee: Animal Technology Institute Taiwan (TW)
Date of First Priority Issue: Tuesday June 1st, 2004
Telomerase promoters sequences for screening telomerase modulators
Patent Number: 7,378,244Division of most mammalian cells is accompanied by reduction in the length of telomeres, which is responsible in part for cellular senescence and death. Some cells, particularly stem cells and cancer cells, express the enzyme telomerase and are not restricted by the "Hayflick Limit". Some data exists to support the concept that...
Inventors: Morin; Gregg B. (Vancouver, CA), Lichtsteiner; Serge (Encinitas, CA), Vasserot; Alain (Carlsbad, CA), Adams; Robert (Redwood City, CA), Andrews; William H. (Reno, NV)
Assignee: Geron Corporation (Menlo Park, CA)
Date of First Priority Issue: Friday May 30th, 2008
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Isolation and expansion of human marrow stromal cells
Patent Number: 7,374,937This patent covers methods of expanding bone marrow stromal cells by culture at low concentrations. The stromal cells described in the patent are very similar in morphology and marker profile to mesenchymal stem cells that are already in clinical trials.Methods disclosed by the patent include ways of inducing proliferation of isolated human bone marrow stromal cells by culturing the cells at...
Inventors: Prockop; Darwin J. (New Orleans, LA), Colter; David (Philadelphia, PA), DiGirolamo; Carla (Milford, MA)
Assignee: Philadelphia Health and Education Corporation (Philadelphia, PA)
Date of First Priority Issue: Friday October 29th, 1999
Methods and compositions for nerve regeneration
Patent Number: 7,374,760Stem cell therapy has successfully been used in various animal models of neurodegenerative diseases including cerebral palsy, demyelinating conditions, and ALS. Stem cells in many situations do not need to differentiate into the cell of therapeutic interest to mediate effects but may simply provide...
Inventors: Zou; Yimin (Chicago, IL)
Assignee: The University of Chicago (Chicago, IL)
Date of First Priority Issue: Thursday May 15th, 2003
In vivo synthesis of connective tissues
Patent Number: 7,375,077The current invention teaches the generation of connective tissue in vivo. Specifically, stem cells that have been differentiated into connective tissue cells, such as fibroblasts, are placed in a scaffold, with two other scaffolds surrounding the scaffold containing the cells. The two other scaffolds on the top and the bottom of the middle scaffold contain growth factors and...
Inventors: Mao; Jeremy Jian (Chicago, IL)
Assignee: The Board of Trustees of the University of Illinois (San Diego, CA)
Date of First Priority Issue: Friday September 19th, 2003
Propagation and/or derivation of embryonic stem cells
Patent Number: 7,371,573This patent covers methods of growing embryonic stem cells outside of the body using novel tissue culture media and media additives. Specifically, it covers the use of compounds that inhibit MEK-1 and/or MEK-2, as well as compounds that activate gp130 for use in stem cell propagation. This claim conceptually blocks anyone from using compounds known and unknown that modulate these...
Inventors: Smith; Austin Gerard (Edinburgh, GB), Burdon; Thomas Grant (Edinburgh, GB)
Assignee: University of Edinburgh (Edinburgh, GB)
Date of First Priority Issue: Friday June 8th, 2001
Nuclear transfer with porcine embryonic stem cells
Patent Number: 7,371,922This patent covers methods of making genetically engineered pigs. This is an important area of study not only from a research perspective, but also that transgenic animals may be used for things such as: a) mass production of proteins; b) donor organs for humans; and c) agricultural purposes.The patent teaches the generation of pigs by:1. Obtaining a pig ES cell whose nucleus has...
Inventors: Wheeler; Matthew B. (Tolono, IL), White; Brett R. (Lincoln, NE)
Assignee: The Board of Trustees of the University of Illinois (Urbana, IL)
Date of First Priority Issue: Wednesday July 31st, 2002
CD56 positive human adult pancreatic endocrine progenitor cells
Patent Number: 7,371,576The quest for a stem cell therapy for diabetes has led to the evaluation of numerous cellular sources ranging from embryonic stem cells, to bone marrow derived stem cells, to mesenchymal stem cells. One interesting method of expanding insulin producing cells is through extraction of pancreatic progenitors...
Inventors: Tsang; Wen-Ghih (Sherman Oaks, CA), Zheng; Tianli (Culver City, CA), Liu; Wei (Cypress, CA)
Assignee: Reneuron, Inc. (Santa Monica, CA)
Date of First Priority Issue: Friday September 6th, 2002
Three dimensional bioengineered smooth muscle tissue and sphincters and methods therefor
Patent Number: 7,368,279This patent covers methods of producing artificial sphincters. Specifically, smooth muscle cells are grown on an extracellular matrix that is placed on a tissue culture vessal coated with polydimethyl siloxane and a mold made of a cylindrical shape which is coated with the same material. Examples of extracellular matrices useful for the invention include fibrin. The patent covers...
Inventors: Bitar; Khalil N. (Ann Arbor, MI), Hecker; Louise (Ann Arbor, MI), Baar; Keith (Dundee, GB), Somara; Sita (Ypsilanti, MI)
Assignee: The Regents of The University of Michigan (Ann Arbor, MI)
Date of First Priority Issue: Wednesday November 24th, 2004