Patents
Method for enriching adherent monocyte populations
Patent Number: 7,393,628Monocytes are generally known as the precursors to macrophages, cells involved in phagocytosing bacteria and injured tissue (thats why in Latin "Macrophage" apparently means "Big Eater"). However, in addition to the classical functions of monocytes, there is evidence to suggest that these cells are potent stimulators of angiogenesis, as...
Inventors: Wagner; Stephen J. (Columbia, MD), Myrup; Andrew (Silver Spring, MD), Celluzzi; Christina (Columbia, MD)
Assignee: American National Red Cross (Washington, DC)
Date of First Priority Issue: Tuesday October 8th, 2002
Prolactin induced increase in neural stem cell numbers
Patent Number: 7,393,830We at StemCellPatents.com believe that the future of stem cell therapy will involve optimization of current therapeutic approaches that are already in clinical trials. For example, it is known that intravenous administration of mesenchymal stem cells can generate statistically significant improvement in heart function after heart attacks. It is also known...
Inventors: Shingo; Tetsuro (Okayama, JP), Weiss; Samuel (Calgary, CA)
Assignee: Stem Cell Therapeutics Inc. (Calgary, Alberta, Canada)
Date of First Priority Issue: Friday September 14th, 2001
Optimization of immunomodulatory properties of genetic vaccines
Patent Number: 7,390,619Activation of T cells normally occurs by antigen presenting cells, of which the dendritic cell is the most potent. T cells require signals from CD80 and CD86 on the antigen presenting cell in order to activate CD28, which is required for escape from anergy. Since the T cell molecule CTLA-4 also binds CD80 and CD86, it is important to preferentially...
Inventors: Punnonen; Juha (Belmont, CA), Stemmer; Willem P. C. (Los Gatos, CA), Whalen; Robert Gerald (Foster City, CA), Howard; Russell J. (Los Altos Hills, CA)
Assignee: Maxygen, Inc. (Redwood City, CA)
Date of First Priority Issue: Wednesday February 11th, 1998
Self-contained adipose derived stem cell processing unit
Patent Number: 7,390,484Adipose tissue is known to contain a variety of different cellular populations. For example, Medistem Inc (mdsm.ob) reported presence of immune suppressive T regulatory cells in adipose tissue that could potentially be useful for inhibiting autoimmunity. Another type of cell found in adipose tissue is endothelial precursor...
Inventors: Fraser; John K. (Los Angeles, CA), Hedrick; Marc H. (Encino, CA)
Assignee: Cytori Therapeutics, Inc. (San Diego, CA)
Date of First Priority Issue: Friday December 7th, 2001
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CD8.alpha..sup.+lymphoid dendritic cell differentiated from human hematopoietic stem cell and a method for differentiation
Patent Number: 7,390,658Dendritic cells are the most potent antigen presenting cell, capable of activating naive T cells, as well as inducing generation of suppressor T cells. Given the potent ability of dendritic cells to stimulate the immune system, they have been used as "natural adjuvants" in cancer therapy. A discussion of the tolerogenic and tolerance...
Inventors: Kim; Hyun-Soo (Suwon-si, Kyungki-do, KR), Lee; Kyung-Bock (Sacheon-si, KR), Kim; Hugh-Chul (Suwon-si, KR)
Assignee: Lifecord, Inc. (KR); FCB-Pharmicell Co., Ltd. (KR)
Date of First Priority Issue: Thursday March 29th, 2001
Cellular therapy to heal vascular tissue
Patent Number: 7,387,645The current patent covers methods of treating/repairing aneurysms through autologous cells, including stem cells by delivering the cells into an aneurysmal site so as to repair the blood vessel. Types of cells useful for practising the invention include bone marrow stem cells, adipose derived stem cells and blood derived stem cells. Addition of various extracellular matrix components...
Inventors: Fernandes; Brian (Roseville, MN), Chu; Jack (Santa Rosa, CA), Ganesan; Prema (San Francisco, CA)
Assignee: Medtronic Vascular, Inc. (Santa Rosa, CA)
Date of First Priority Issue: Friday April 25th, 2003
Composition and method for inducing and enhancing a telomerase reverse transcriptase-reactive cytotoxic T lymphocyte response
Patent Number: 7,388,071Telomerase is an enzymatic complex that repairs the telomeric ends of chromosomes so as to allow certain cells to escape senescence. Various stem cells, including some adult stem cells, express telomerase. Most importantly, tumors express this complex and it is what allows them to continue proliferating without undergoing senescence.A very interesting approach to the...
Inventors: Zanetti; Maurizio (La Jolla, CA)
Assignee: The Regents of the University of California (Oakland, CA)
Date of First Priority Issue: Tuesday February 15th, 2000
Aligned scaffolds for improved myocardial regeneration
Patent Number: 7,384,786Stem cell therapy for cardiac indications may take a variety of forms. One of the easiest is intravenous administration of mesenchymal stem cells after a myocardial infarction. This would require the stem cells to selectively home into damaged tissue. It is known that various inflammatory agents such as IL-18 and
Assignee: Scimed Life Systems, Inc. (Maple Grove, MN)
Date of First Priority Issue: Wednesday July 16th, 2003
Compositions and methods for detecting and treating motor neuron disorders
Patent Number: 7,384,748The issued claim in the current patent covers a method of diagnosing a motor neuron disease based on sequences associated with mutations in the neuropathy target esterase (NTE) gene. If one reads the specification, descriptions of treatments based on inhibiting expression of the mutated NTE gene using techniques such as siRNA are disclosed. Genetic complementation using stem cells are also...
Inventors: Fink; John K. (Ann Arbor, MI), Rainer; Shirley (Sylvania, OH)
Assignee: The Regents of the University of Michigan (Ann Arbor, MI)
Date of First Priority Issue: Monday December 13th, 2004
Use of cytokines and mitogens to inhibit graft versus host disease
Patent Number: 7,381,563Hematopoietic stem cell transplantation has saved hundreds of thousands of lives of patients with hematopoietic malignancies or some metabolic disorders. Hematopoietic stem cell transplant involves administration of CD34 cells or unpurified mononuclear cells from either donor bone marrow, cord blood, or mobilized peripheral blood. Since the "graft" in this type of...
Inventors: Horwitz; David A. (Santa Monica, CA)
Assignee: University of Southern California (Los Angeles, CA)
Date of First Priority Issue: Tuesday March 3rd, 1998