Category: Expansion (13)
Lithium for Treatment of Multiple Sclerosis
This video describes a publication which used the experimental allergic encephalomyelitis model of multiple sclerosis to test immunological effects of lithium. The authors demonstrated profound inhibition of disease, as well as stimulation of antiinflammatory cytokines. It seemed like the anti-inflammatory effects of lithium were...
FGF-1 Gene Therapy Double Blind Trial
Münster, Germany -
Understanding and manipulating the formation of new blood vessels, a process called angiogenesis, has been one of the highly sought-after goals of the biotechnology industry. One the one hand, inhibition of angiogenesis is desirable in cancer, since tumors need new blood vessels to stay alive. On the other hand, angiogenesis stimulation could...
Supercharged Mesenchymal Stem Cells
Kobe, Japan - The ability to expand stem cells in culture without their differentiation is one of the features that makes embryonic stem cells attract a lot of attention. For example, in one of the classical WARF patents, the claim is made regarding ability of the embryonic stem cell to proliferate in...
Extending Beta Cell Survival with Exendin-4
Toronto, Canada - Exendin-4 is an agonist of GLP-receptor 1, which is involved in not only increasing the mass of pancreatic beta cells, but has also been implicated in the stimulation of new neuron generation. In addition to exendin-4, agonists of the glucagon-like receptor include various incretin...
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Telomerase important in epidermal stem cells
Madrid, Spain - Shortening of telomeres is associated with cellular senescence. However, the shortening of telomeres is known to be associated not just with cell death but also dysfunction. For example, associations have been previously made between hypertension and telomere shortening (Fuster et al. Telomere dysfunction in hypertension. J Hypertens. 2007 Nov;25(11):2185-2192). In a...
Systemic Administration of Endogenous Stem Cell Activator
Frankfurt, Germany -
Valproic acid is a histone deacetylase inhibitor which is clinically used for the treatment of bipolar disorders and epilepsy. Valproic acid has been demonstrated to increase proliferation and expansion of CD34 stem cells in vitro. Additionally,
Bone Marrow Stem Cell Expansion for Bone Formation
Cleveland, Ohio – Numerous studies have shown therapeutic potential of bone marrow derived stem cells for accelerating healing of bone injuries. Unfortunately, to date, few in vitro bone marrow stem cell expansion systems exist that can produce scalable quantities of stem cells in a easy to use and widely applicable manner. Recently, a paper (Dennis et al. Clinical-scale Expansion Of a...
Stem Cell Expansion by Valproic Acid
[Watch the Video] This video overviews a paper describing the ability of valproic acid (a clinically used drug for treatment of neurological disorders) to induce expansion of hematopoietic stem cells. It will be interesting to see if valproic acid can also induce expansion of other types of stem cells in vivo.
HOXB4 synergizes with p21 KO
Lasers and Stem Cells
Tel-Aviv, Israel - The use of low level laser irradiation to promote healing has been documented clinically (Lagan et al. Low-intensity laser therapy/combined phototherapy in the management of chronic venous ulceration: a placebo-controlled study. J Clin Laser Med Surg. 2002 Jun;20(3):109-16). Since some authors believe that low level laser irradiation possesses mitogenic effects for...