Stem Cell Therapy for Kidney Failure

Saturday August 25th, 2007 @ 19:16:18 EST

From Category: Use

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This video describes the use of bone marrow mesenchymal stem cells for the treatment of renal failure in an animal model. It summarizes a publication that demonstrates systemic administration of 1 million mesenchymal stem cells not only reduces serum creatinine post ischemia reperfusion injury, but also that these cells play an antiapoptotic and anti-inflammatory role.


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26 Comments | Add Comment

Kavitha said...

Created 2007-10-18 05:32:13 EST


has stem cell therapy been carried out on human beings with renal failure?

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Stemcellgood said...

Created 2007-10-18 15:53:19 EST

I do believe that Cellmedicine (www.cellmedicine.com) has treated chronic renal failure associated with type II diabetes. They are the ones who put up that video.

Intravenously administered autologous stem cells derived from fat tissue or bone marrow should have regenerative properties after acute tubular necrosis, as well as more chronic types of renal injury.

The mechanisms of action are really interesting since it appears to completely due to transdifferentiation but actually angiogenesis and indirect secretion of growth factors.

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satheesh.nambiar said...

Created 2007-12-26 06:15:12 EST

is stem cell therapy is useful for patients who have chronic alographt nephropathy (had their kidney transplanted earlier)

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StemCellPatents.com said...

Created 2007-12-28 20:47:43 EST

Conceptually stem cell therapy should have effects in chronic rejection. Although to our knowledge clinical trials have not been conducted, preclinical animal data supports this. For example, mesenchymal stem cells are known to be tolerogenic and at the same time promote regeneration of various tissues. One ideal treatment method would be use of autologous (recipient) mesenchymal stem cells so as to not only accelerate healing of the injured tissue but also make the graft into a type of "chimera" so as to decrease immunogenicity.

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Ramya said...

Created 2008-01-29 23:29:11 EST

Is there is any stemcell therapy for ALS,still any animals studies or clinical trails going on....

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Jon Amorin said...

Created 2008-01-30 10:18:48 EST

You know the thing with ALS? The pateint advocate community is so so set against stem cells, almost a paranoia or something, that I dont even bother to talk about ALS and stem cells to people. See for one reason or another everyone who has ALS is so jaded that if I was to offer stem cell information, you would just go and critize it anyway. I went to this ALS forum or whatever its called and was personally humiliated when I started asking about stem cells. So I think that it is better for you not even to ask about stem cells and ALS because it is a very touchy subject.

That being said, there are plenty of trials going on. People are so ignorant and think that stem cell therapy is only something that is used offshore or something that is "alternative medicine" or involves killing babies.

Stem cell therapy is alive and well in the USA and Europe and Japan. Specifically, if you need to know about ALS and stem cells, there is a link on this site that talks about it.

There have been some successful clinical trials in italy using mesenchymal stem cells for the treatment of ALS

There is also work being performed in the USA. One other thing i have heard is that there is a doctor Ghenn who is getting successes using cord blood stem cells for ALS.

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Nathan said...

Created 2008-01-31 21:48:52 EST

what in the world does ALS have to do with kidney disease? well maybe similar regenrative cytokines?

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osama said...

Created 2008-02-06 17:31:03 EST

please i need to send to me some papers or articles in stem cell therapy for renal failiur

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nadaili said...

Created 2008-03-31 08:19:06 EST

is there any possibility of cureing chronical kidney failure ?

is it in procedure in lany of aboratories arond the world or ... ?

who is the most advanced in the field of applaying of stem cells in cureing chronical kidney failure ?

are there any "predictions" in the field or promising investigations for the future ?

 

thanks

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aussieshelia said...

Created 2008-04-10 07:44:07 EST

G'Day everyone, why am I here, well I'm not sure, I guess I'm looking for an answer like alot of others, I googled als succussful stem cell treatment and ended up here.... and would just like respond to the post from Jon Amorin in ref., to the negetivity from the ALS "support" system in regards to stem cell therapy. My hubby is 32 has been dx with ALS and has basically been told to go home and get ready to die. Well with two babies under two and two teens, that isn't acceptable to me..... I am a radio announcer in Australia and one morning recieved a news release about placenta implants and the benifits for those living with ALS, I scoured every media contact I had to try to get someone to repond or find out more - no one would even consider it - not even supposed ALS support centre, nor our Neurologist, not even support chat rooms, as far as they were concerned, stem cell therapy is a myth and a money grabber from desperate people. (I have even been banned from ALS chat rooms for advocting stem cell treatments for ALS!!! How stupid is that!!!!)

Rayma - yes there are some therapies, not that either Australia or the USA accept them. Australias leading stem cell dudes are leaving the country to go where they aren't constricted in their research. We are about to head to Mexico for treatment, placenta implant treatment by a Dr Omar Gonzalaz, www.stemcellkp.com Will it work, well we don't know, but do we sit back and not try, passing on the chance we may have a few extra years... No. We know that stem cell implants are only a treatment not a cure for ALS, but from treatments come cures and I hope that our treatment may lead the way for someone elses cure...

For whatever reason you are looking at Stem Cell treatment, I pray it all goes well for you.... Kylie

- 10 -

StemHope said...

Created 2008-05-23 13:45:08 EST

DIAGNOSIS:  Bulbar ALS  – January, 2005

REASON FOR COMING FOR TREATMENT:  First symptoms started in June 2004. The disease progressively got worse until right before the treatment when he was confined to a wheelchair and had limited use of his hands.

TREATMENT:  Umbilical Cord Stem Cell and Nerve Growth Factor Injections with Rehabilitation Therapy

START OF TREATMENT:  February 12, 2006

BEFORE THE TREATMENT:  He could not get up out of his wheelchair without assistance and would otherwise risk losing his balance.  He could only raise his hands to chest when laying on a bed. He had trouble swallowing. He could not move his facial muscles well or stick out his tongue. He was taking Baclofen, 10 mg, three times a day to prevent muscle spasticity. 

See Videos - Interview , Kelly Stands Up and Kelly Adjusts His Wheelchair 

AFTER THE TREATMENT:  He had increased mobility in his hands. He could get out of his wheelchair by himself. He could walk on his own. He had an easier time swallowing. He could move his facial muscles when having a shave. He could stick out his tongue. He could turn his hands out more and move them out to the sides more. He only needed to take Baclofen 10mg once every one or two days.  

OTHER NOTES:  Kelly was on a high protein diet and taking a cocktail of medicines including the experimental drug IGF which he feels may have helped to make the stem cells more effective more quickly. When Kelly came for the treatment, he did not bring his IGF but was able to substitute HGH for it. HGH raises the level of IGF in the body. Soon after hearing that Kelly was taking HGH, the other ALS patients wanted it too.

- 11 -

StemHope said...

Created 2008-05-23 13:53:42 EST

IF you are seeking Stem Cell Therapy or information please let me know stemhope @ gmail . com

The treatment above took place in Bangkok Thailand and cost way less than most places in the world. here is a list of other treatments available with this technology

Diseases treated with cord blood
Beginning in the late 1980s, cord blood stem cells have been used to treat a number of genetic diseases, cancers, and blood disorders. Among the approximately 75 diseases and disorders currently treated are:

A-D

E-L

M-Z

Adrenoleukodystrophy

Agnogenic myeloid metaplasia

Amegakaryocytic thrombocytopenia

Amyloidosis

Anemia:

Aplastic anemia

Blackfan-Diamond anemia

Congenital dyserythropoietic anemia

Cooley's anemia (Beta thalassemia major)

Fanconi's anemia

Refractory anemia

Severe aplastic anemia

Sickle-cell disease

Aspartylglucosaminuria

Congenital cytopenia

Cancer:

Brain tumors

Ewing's sarcoma

Multiple myeloma

Neuroblastoma

Ovarian cancer

Renal cell carcinoma

Small-cell lung cancer

Testicular cancer

Waldenström macroglobulinemia

Chediak-Higashi syndrome

DiGeorge Syndrome Dyskeratosis congenita

Evan syndrome

Glanzmann thrombasthenia

Gunther's disease

Hunter syndrome

Hurler syndrome

Kostmann syndrome

Krabbe disease

Langerhans cell histiocytosis

Lesch-Nyhan syndrome

Leukemia:

Acute biphenotypic leukemia

Acute lymphocytic leukemia

Acute myelogenous leukemia

Acute undifferentiated leukemia

Chronic lymphocytic leukemia

Chronic myelogenous leukemia

Chronic myelomonocytic leukemia

Juvenile chronic myelogenous leukemia

Juvenile myelomonocytic leukemia

Plasma cell leukemia

Prolymphocytic leukemia

Lymphocyte adhesion disease

Lymphoma:

Burkitt's lymphoma

Hodgkin's disease

Non-Hodgkin's lymphoma

Lymphoproliferative syndrome

 

Metachromatic leukodystrophy

Morquio syndrome

Multiple sclerosis

Myelokathexis

Neutrophil actin deficiency

Nezelof syndrome

Niemann-Pick disease

Omenn syndrome

Osteoporosis

Paroxysmal nocturnal hemoglobinuria

Polycythemia vera

Pure red cell aplasia

Reticular dysgenesis

Rheumatoid arthritis

Sandhoff Disease

Sanfilippo syndrome

Scheie syndrome

Shwachman-Diamond syndrome

Sialidosis

Severe combined immunodeficiency (SCID)

Sly syndrome

Systemic lupus erythematosus

Tay-Sachs disease

Thalassemia

Wiskott-Aldrich syndrome

Wolman disease (xanthomatosis)

X-linked Hyper IgM Syndrome

X-Linked lymphoproliferative disorder

 

- 12 -

Christineball33 said...

Created 2008-05-24 10:57:27 EST

Wow StemHope that is quite something?  Can you please tell us a little more about the types of stem cells that you use?  How do we know that they do not cause cancers or abnormal growth. 

Also is StemHope related to www.cellmedicine.com ?

 

Thank you

Christine 

 

 

- 13 -

StemHope said...

Created 2008-05-29 00:34:59 EST

Hi Christine,

The 2 stem cells we generally use are Adult Stem Cells, which come from the patients themselves, the only side effect to this treatment is no effect at all. The other type are called CBSCs (Cord Blood Stem Cells) The umbilical cord blood from healthy full term newborns with healthy mothers is the only source of stem cells. Given the woman’s consents to donate her umbilical cord, immediately after the delivery, authorized hospital personnel insert a needle into the cord’s vein and the blood is drawn, normally from 80 to 120 ml. The cord blood is then put into a small, sterile pouch with an anticoagulant to prevent clotting. The pouch contains from 100,000 to 300,000 stem cells.

The umbilical cord blood is then immediately sent to the blood bank for testing. First of all, a medical history of the mother is reviewed. Then, the blood is tested to ensure that no genetic disorders, microbiological contamination and/or hereditary diseases exist, such as HIV, Syphilis, CMV, HTLV and Hepatitis. Provided the blood passes all tests, it receives a certification of purity and is then transferred to laboratory.

Here, the blood is tested one more time to confirm the blood banks results. This double check ensures total safety to our patients. After the blood has been cleared it undergoes a process known as magnetic washing, aimed at removing all material except the specifically desired stem cells by means of magnetic beads coated with antibodies to stem cell antigens.
CBSCs generally have a higher success rate but are more costly.

As for the second part of the question I am not affiliated to cellmedicine. However, do reside in the ridiculously hot state of Florida ":) thats my sweaty forehead lol! After a brief review of their site I saw that they do not offer CBSCs which have shown greater success rates in many case studies. It is amazing to think that within the past few years all the disease I listed above have become treatable by this breakthrough in medicine. I am excitted to see what the Earth will be like in 10 more years, the retirement age is going to be like 85 soon! Thanks for the??? hope you all have a great day.

SH

- 14 -

isuhaider said...

Created 2008-09-14 05:31:30 EST

Hello

My 4yr old son suffers from chronic renal failure secondary to PUV. I am interested in stem cell therapy for my son can you please direct me as to where I can go?

- 15 -

isuhaider said...

Created 2008-09-17 04:58:56 EST
Please is there treatment out there for chronic renal failure as I would like to explore this for my 4yr old son. Please HELP!
- 16 -

StemCellPatents.com said...

Created 2008-09-19 01:49:27 EST

Several clinics have experience with using adult stem cells for a variety of degenerative conditions.  As the video teaches, there is scientific rationale for why some of these treatments may work, unfortunately, proper randomized clinical trials have not been performed for kidney failure (for heart failure they have been performed with positive results).  You may want to contact www.cellmedicine.com and see if they had any experience with kidney failure.  Given that they appear to be the world authority on applying cutting edge science.  Best wishes

StemCellPatents.com 

 

- 17 -

StemCellPatents.com said...

Created 2008-09-19 01:49:42 EST

Several clinics have experience with using adult stem cells for a variety of degenerative conditions.  As the video teaches, there is scientific rationale for why some of these treatments may work, unfortunately, proper randomized clinical trials have not been performed for kidney failure (for heart failure they have been performed with positive results).  You may want to contact www.cellmedicine.com and see if they had any experience with kidney failure.  Given that they appear to be the world authority on applying cutting edge science.  Best wishes

StemCellPatents.com 

 

- 18 -

sohail said...

Created 2008-12-03 09:28:37 EST

 

 

Mr Isuhaider you can try www.regencell.com this is the website for regencell they are using mesenchymal stem cells for treaing a lot of disorders.Insha allah you might just come across something.

 

- 19 -

sohail said...

Created 2008-12-03 09:30:35 EST
Mr Isuhaider you can go to this website and try out your luck www.regencell.com they are using mesenchymal stem cells to treat a lot of disorders.Best of luck.
- 20 -

sohail said...

Created 2008-12-03 09:32:18 EST
  • Mr. Isuhaider you can try www.regencell.com .
  • best f luck.
- 21 -

sohail said...

Created 2008-12-04 00:24:10 EST

 

 Mr.Isuhaider  as stemcellgood said tht cellmedicine has treated patient with crf u can als try alternately you can try this website www.regencell.com they are using mesechymal stem cells for tretment.Best of luck.....

- 22 -

isuhaider said...

Created 2009-01-20 19:15:08 EST

Hi

does anyone know if china is doing fetal stem therapy for chronic renal failure? Sohail I tried the link that you gave me but there is nothing to go on there the page is still under construction.

 

- 23 -

oren41 said...

Created 2009-03-11 11:50:01 EST
Hello, I am a dialysis patient due to Iga-Nephropathy leading to my renal failure.. Im not interested in the current methods of transplantation due to the anti rejection drugs..IM very interested in stem cell treatment for renal failure, As i see theres many others like me who are seeking help. Does anyone know of any clinical trials involving stem cells and renal failure ? if so please contact me ( orenjeansonne@att.net )..
- 24 -

oren41 said...

Created 2009-03-11 11:51:48 EST
Id like more info on stem cell treatments involving renal failure, is help available ? please contact me ( orenjeansonne@att.net) thanks
- 25 -

Dr Sunil W said...

Created 2010-02-20 23:20:03 EST

Hi everybody,

                      I am dr sunil from spectrum cell clinic india. stem cell medicine works for chronic kidney disease.

We use autologous stem cells for CKD associated with diabetes and umbilical cord stem cells for autoimmune CKD. The website www.spectrumcellclinic.com could be contacted for further details.

Regards,

Dr Sunil Waghmare

md,mbbs,dmre,macp,facp,Fellow ISVIR

interventional radiologist and stem cell therapist. 

- 26 -

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