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Dear manoj kumar valluru,

Last week the Canadian company Sernova was issued a patent covering the use of Sertoli cells to deliver essentially any gene in vivo (#7,399,751) without evoking an immune response. Given that the company already has clinical proof of concept data on its lead product, Sertolin, for treatment of Type I Diabetes, this will be an interesting one to watch. Speaking of immunology, a very unorthodox approach to treating neural injury was presented in a patent (#7,399,740) covering a peptide polymer that INHIBITS T regulatory cells. Angioblast Systems scored nicely getting a key patent on its mesenchymal precursor cell (#7,399,632).

An interesting news item, Habib's group from England reported that injection of 9 patients with autologous expanded CD34s had clinical improvement...but people (a certain scientist from Stanford) say that CD34s only make blood...how is this possible !?!? (we are being ironic).

 

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Production of a biological factor and creation of an immunologically privileged environment using genetically altered Sertoli cells
 
 
Patent Number: 7,399,751

This is a patent with priority in 1999 describing the use of genetically modified Sertoli cells for immune protection of implanted cells AND the use of the Sertoli cells themselves as the vector...genetic engineer with any gene is covered.

This patent is part of the Canadian company Sernova's ([Read More]

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  Clinical Trial of CD34 Stem Cells for Liver Failure

Sunday July 20th, 2008 @ 15:05:23 EST

London, UK-

The use of stem cells to treat liver failure is not new. Animal models, as well as pilot clinical trials have demonstrated statistically significant improvement in liver enzyme values and overall clinical scores.

In a recent study (Pai et al. Autologous...[Read More]

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