StemCellPatents.com Newsletter

Hello manoj kumar valluru,

Last week Geron increased its hold on the embryonic stem cell field by issuance of a patent, #7,425,448, teaching the generation of cardiomyocytes from cultures of ES cells.  Another interesting patent was issued, #7,425,545, that claims antisense oligonucleotide sequences for suppression of C Reactive Protein.  This is of interest to the area of stem cells since C reactive protein is one of the inflammatory agents associated with demise of stem cell activity in aging.  Additionally, CRP has been shown to directly kill endothelial progenitor cells (Fuji et al. C-reactive protein alters antioxidant defenses and promotes apoptosis in endothelial progenitor cells. Arterioscler Thromb Vasc Biol. 2006 Nov;26(11):2476-82).  Thus it will be exciting to see if the techniques in this patent will be used together with stem cell therapy.

An interesting paper was published last week demonstrating that exercise increases neural stem cell number and activity in middle aged mice.  The company Stem Cell Therapeutics has developed a drug candidate pipeline, some of which are in Phase II, on the basis of replicating the stimulation of neural stem cells found in pregnancy by identifying the various hormones responsible for this, such as human chorionic gonadotrophin and prolactin.  If exercise increases neural stem cells through other mechanisms, perhaps similar commercialization of these concepts will also occur. 

Exercise Increases Neural Stem Cells Monday September 22nd, 2008 @ 09:58:03 EST Taiwan - Neural stem cells are known to exist in post-natal animals. For example, during pregnancy, an increase in mitotic cells has been reported in the brains of the mother. This has been ascribed to numerous hormones and growth factors, including prolactin and human chorionic gonadotrophin. Furuta et al. (Gestation-induced cell...[Read More] Ask a question OR leave your comments. Read more StemCellPatents.com News

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