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Hello manoj kumar valluru,

A very interesting patent was issued last week, #7,553,661, covering the use of mesenchymal stem cells as antigen presenting cells.  In order to induce antigen presenting function the cells are stimulated with interferon gamma.  Uses for this patent may include tolerogenic vaccines. 

Patent #7,553,663 granted to Blasticon covers the treatment of liver failure using hepatocytes generated from dedifferentiated monocytes.  This IP seems a little related to with Opexa is working on.  It will be interesting to see whether there will be any interactions between these companies.

Noteworthy publications last week included a paper by Herr et al demonstrating that apoptotic bodies induce macrophages to secrete angiogenic factors...this makes us wonder...could we simply just use extracorporeal ozonization or photopheresis to achieve angiogenesis clinically?  People in the alternative medicine community have been saying this for decades now.

Stromal antigen-presenting cells and use thereof     Patent Number: 7,553,661 Assignee | Inventor Mesenchymal stem cells are known to possess a variety of immune modulatory activities such as suppression of allogeneic responses, as well as induction of T regulatory cells.  Mechanisms include expression of IDO and HLA-G.  Mesenchymal stem cells...[Read More] Ask a question OR leave your comments.

Apoptotic Cells Secrete Angiogenic Factors Saturday June 27th, 2009 @ 03:54:59 EST It is a medical mystery why approaches such as extracorporeal ozone therapy or even photopheresis seem to have therapeutic effects in certain situations.  One possibility is that stressing of cells outside of the body causes formation of apoptotic bodies, with the apoptotic bodies having a therapeutic...[Read More] Ask a question OR leave your comments. Read more StemCellPatents.com News

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