News Posts
Therapeutic Immune Modulation by Stem Cells
Genoa, Italy - As more and more clinical data emerges in the area of stem cells, there will come a time when the medical community starts to appreciate aspects of stem cells that have little to do with regeneration. One such aspect is the ability of stem cells to perform functions such as immune modulation. A recent study (Gerdoni et al. Mesenchymal stem cells effectively modulate...Wednesday March 28th, 2007 @ 13:36:05 EST
ES to Blood: Role of TPO
San Diego, California - The role of the mpl ligand thrombopoietin (TPO) in upregulating production of megakaryocytes is established in the literature. Interestingly, it is also noted that TPO may have functions at inducing self-renewal of early hematopoeitic stem cell progenitors. In a recent study, the ability of TPO, as well as the angiogenic cytokine vascular endothelial growth...Monday March 26th, 2007 @ 02:05:19 EST
OCT-4 Challenged
Milan, Italy - The ability of molecular and cellular biologists to distinguish cells of various potency in terms of "stemness" is greatly assisted by specific cellular markers. For example, hematopoietic stem cells are known to contain the marker CD34, which acts as an adhesion molecule, but also is somewhat specific to cells capable of producing other blood cells. CD34 for purification of...Monday March 26th, 2007 @ 01:50:22 EST
StemCellPatents.com Applauds Osiris
StemCellPatents.com Applauds Osiris Therapeutics for First Intravenous Allogeneic Stem Cell Clinical Data Mar 25 2007, 3:21 PM EST Business Wire StemCellPatents.com congratulates Osiris Therapeutics for promising data reported today using the PROVACEL™, adult mesenchymal stem cell product for treatment of post myocardial infarction patients. The data, which was presented by Joshua...Sunday March 25th, 2007 @ 20:38:53 EST
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Bone Marrow Changing to Liver
New Delhi, India - There are numerous reports in the literature of bone marrow cells "transdifferentiating" into hepatocytes, or alternatively, bone marrow cells having hepatic precursors that can differentiate into hepatocytes. The possibility of this occuring is substantiated by studies in sex mismatch clinical bone marrow transplant recipients in which liver biopsies from the recipient...Saturday March 24th, 2007 @ 14:45:47 EST
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Stem Cell Analgesia
Atlanta, Georgia - There are currently numerous clinics utilizing stem cell therapies for a wide variety of indications ranging from ALS to autism. These stem cells are usually cord blood derived, or autologous bone marrow cells. Although little mechanistic work has been performed, the clinical use of stem cells is associated with patients having favorable subjective responses. A recent...Friday March 23rd, 2007 @ 19:23:46 EST
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Sugar in the brain
Tokyo, Japan - It is known that a wide variety of factors are capable of inducing neurogenesis in the adult brain. For example, post-stroke neurogenesis is known to be at least partially dependent on eryothropoietin signaling (Tsai et al. A critical role of erythropoietin receptor in neurogenesis and post-stroke recovery. J Neurosci. 2006 Jan 25;26(4):1269-74.). Administration of...Saturday March 17th, 2007 @ 15:25:29 EST
Nucleostemin and lens regeneration
Kobe, Japan - It is known that in the newt, regeneration of differentiated cells occurs in response to various types of injury. It is also known that the gene for nucleostemin (NS) encodes a GTP-binding protein which is found in the nucleolus of stem cells and cancer cells at high concentrations. Accumulation of nucleostemin in the nucleolus of pigmented epithelial cells is also noted...Saturday March 17th, 2007 @ 15:06:10 EST
Therapeutic ES Cells
Nara, Japan - Liver cirrhosis afflicts numerous members of population, being the result of excessive fibrosis which ends in hepatic decompensation and death. To date little is available in terms of therapeutic solutions for advanced cirrhosis. Accordingly, the use of stem cells for this indication is promising. In a recent paper (Moriya et al. Embryonic stem cells develop into hepatocytes...Wednesday March 14th, 2007 @ 15:40:27 EST
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Stem Cells Getting Old
Iowa City, IA- Although autologous bone marrow is currently investigated clinically for numerous indications, one of the fears is that old stem cells may lose regenerative ability with age, and as a result be less effective as opposed to other stem cell sources such as cord blood. A recent publication (Zheng et al. Impact of aging on rat bone marrow-derived stem cell chondrogenesis. J...Wednesday March 7th, 2007 @ 20:29:26 EST