News Posts
Exercise Increases Neural Stem Cells
Taiwan - Neural stem cells are known to exist in post-natal animals. For example, during pregnancy, an increase in mitotic cells has been reported in the brains of the mother. This has been ascribed to numerous hormones and growth factors, including prolactin and human chorionic gonadotrophin. Furuta et al. (Gestation-induced cell proliferation in the rat brain. Brain Res Dev Brain Res...Monday September 22nd, 2008 @ 09:58:03 EST
Low Hematopoietic Stem Cells in Alzheimer's?
Tübingen, Germany -The chemokine SDF-1 is known to attract hematopoietic stem cells and mesenchymal stem cells. Under basal conditions it is produced by the bone marrow stromal cells, this is why hematopoietic stem cell transplants can be performed by intravenous administration and they find their way back to the bone...Friday September 12th, 2008 @ 23:29:24 EST
Chronic Inflammation Inhibits Endogenous Neural Stem Cells
Valencia, Spain -Mesenchymal stem cells are widely known to possess anti-inflammatory and immune modulatory activity. The regenerative and trophic functions of this type of stem cell may actually be less important than their ability to block pathological cytokine expression. In fact, the first non-hematopoietic stem cell...Tuesday September 2nd, 2008 @ 15:17:43 EST
Why the hype about in vivo reprogramming?
Cambridge, MA-You may have seen the widespread media coverage last week describing the "reprogramming" of pancreatic cells into insulin producing "islet-like cells". Essentially, all the buzz was about a paper (Zhou et al. In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature 2008 Aug 27) in which differentiated pancreatic exocrine cells (not the...Sunday August 31st, 2008 @ 17:08:24 EST
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Limbs Saved by Medistem's Endometrial Regenerative Cells
San Diego CA-A publication (Murphy et al Allogeneic endometrial regenerative cells: An "off the shelf solution" for critical limb ischemia? J Transl Med. 2008 Aug 19;6(1):45) led by the internationally renowned vascular surgeon Dr Michael Murphy...Sunday August 24th, 2008 @ 17:29:22 EST
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TLRs and Stem Cell Mobilization
Cornell University, New York City, New York -We have discussed on StemCellPatents.com how various inflammatory stimuli may one the one hand act as stem cell chemo-attractants, and on the other hand may actually cause mobilization of stem cells to leave the bone marrow. For example, injured tissue is associated with platelet activation, causing release of agents such asAllogeneic MSC for Restenosis
Naples, Italy -The inherent antiinflammatory activities of mesenchymal stem cells have been leveraged for treatment of diseases associated with uncontrolled production of inflammatory mediators such as graft versus host disease and Crohn's Disease. Indications for which mesenchymal stem cells are currently inTooth in the Brain: Tooth Mesenchymal Stem Cells Made into Neurons
Kaohsiung, Taiwan -The ability of mesenchymal stem cells to differentiate into neurons and neuron-like cells has been documented. For example, mesenchymal stem cells have been demonstrated to be beneficial in case reports of multiple sclerosis, as well as in early clinical trials. Usually mesenchymal stem cells are extracted...Sunday August 10th, 2008 @ 15:18:00 EST
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Exosomes as a means of immune escape
San Diego, CA -It has been widely known for more than a century that activation of immune responses can in some situations cause tumors to regress. This has been the basis for thousands of clinical trials using various proteins as therapeutic vaccines, which aim at inducing the immune system to kill cancer. These trials have had mixed results. One possibility...Sunday August 3rd, 2008 @ 15:39:52 EST
Mesenchymal Stem Cells Inhibiting Homeostatic Proliferation
Felix Platter -Spital, Switzerland - Immune regulatory effects of mesenchymal stem cells include suppression of allogeneic lymphocyte proliferation, stimulation of T regulatory cells, and secretion of soluble immune suppressive molecules such as soluble HLA-G.In a recent paper (Bocelli-Tyndall et...Friday July 25th, 2008 @ 20:50:32 EST
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