Class: Extraction/Preservation (156)
Isolation, selection and propagation of animal transgenic stem cells
Patent Number: 6878542This patent appears to be a really unique way of expanding stem cells. Essentially the patent teaches to connect a growth factor receptor to a promoter that is only expressed on stem cells, such as the promoter for Oct-4. This way stem cells will express the growth factor receptor. This way if you add the ligand for the receptor the stem cells will proliferate...
Method of enriching for mammalian stem cells
Patent Number: 6146888In this patent an antibiotic resistance gene is placed under the control of a promoter associated with stem cells. This way only the stem cells will live while the other cells will die when exposed to the antibiotic.
Myocardial grafts and cellular compositions useful for same
Patent Number: 6399300This patent teaches ways of purifying out cells expressing myocardial genes from a heterogeneous population of stem cells. Specifically the patent teaches the use of cardiac specific promoters driving expression of markers that can be used to take the cells desired out of a heterogeneous population of cells.
In vitro method for producing differentiated universally compatible human blood cells
Patent Number: 5811301This patent teaches ways of genetically modifying stem cells, and their progeny so as to generate a population of cells that is acceptable by all humanity.
Method to distinguish hematopoietic progenitor cells
Patent Number: 6555324This patent covers methods for identifying hematopoietic stem cells based on expression of markers such as CD34, CD38, and various growth factor receptors.
Compositions and methods for producing and using homogenous neuronal cell transplants
Patent Number: 7011827This patent covers the use of the human NT2N neurons for treatment of brain injury. Essentially, the NT2N cells are a cell line derived from a human teratocarcinoma which have neuronal properties., specifically, the cells are post-mitotic since the original teratocarcinoma cell is induced to differentiate into neurons which retinoic...
Method for producing a highly enriched population of hematopoietic stem cells
Patent Number: 5681559This patent teaches the extraction of hematopoietic stem cells from fetal sources. It may be that these stem cells have more potent repopulating activity as compared to stem cells from sources.
Isolation, selection and propagation of animal transgenic stem cells
Patent Number: 7,256,041This patent covers the use of genetic markers to "fish out" stem cells from a heterogeneous population. Essentially, the patent teaches:
1. Culturing mammalian cells with a construct in which a selectable marker is turned on by a promoter which is only active in stem cells.
2. Isolating stem cells based on the selectable marker.
This is a very broad patent Inventors: Smith; Austin Gerard (Edinburgh, GB), Mountford; Peter Scott (Melbourne, AU)
In vitro activation of mammalian oocytes
Patent Number: 6680199This is one of the patents that teaches how to activate oocytes into parthenogenesis (ie without the male side). This patent is useful for generation of pathenogenically-derived embryonic stem cells.
Method for production of neuroblasts
Patent Number: 6045807This patent teaches how to make immortalized neurons through differentiation of neuronal stem cells and then transfection with various genes. These immortalized cell lines can subsequently be used for treatment of neurodegenerative conditions.