Class: Extraction/Preservation (156)
Method for isolating cells expressing flk-2
Patent Number: 6960446fetal liver kinase 2 (flk-2) is expressed on numerous types of stem cells. This patent covers isolation of cells expressing this marker using either a monoclonal or polyclonal antibody. The patent has 1 independent claim which essentially covers the subject matter previously mentioned. The importance of flk-2 on hematopoietic stem cells was published by the author (Matthews W, et al. A...
Monoclonal antibodies for human mesenchymal stem cells
Patent Number: 5837539This patent covers the use of specific antibodies for the isolation and detection of mesenchymal stem cells. The antibodies are deposited at ATCC and can be purchased publically.
Continuous centrifugation process for the separation of biological components from heterogeneous cell populations
Patent Number: 5641622This patent covers the use of continuous flow centrifuges and various systems for purification of homogeneous cells from a heterogeneous population. This patent may be useful for purifying stem cells from blood based on weight and other physical characteristics.
IL-4 and TNF induce mAb 6G10-recognized expression on bone marrow stromal cells
Patent Number: 5206345This patent covers a molecule associated with adhesion of cells to the endothelium that is induced by IL-4 and TNF and is recognized by the antibody 6G10 . This molecule may be important in order to alter migration not only of stem cells but also in situations where migration of cells is sought to be avoided such as cancer.
Phenotypic characterization of the hematopoietic stem cell
Patent Number: 5840580This patent covers the combination of various phenotypic markers for the extraction of hematopoietic stem cells. For example, CD34+, CD38-, HLA-DR- is one phenotype of hematopoietic stem cell described.
Identification and isolation of human hematopoietic stem cells
Patent Number: 5643741This patent covers the identification of human hematopoietic stem cells by seeking out cells that express the markers CD34 and Thy1.
Apparatus for removing fluid from an umbilical cord
Patent Number: 5171527This patent provides a medical device for rapidly extracting cord blood from an umbilical cord. This may be useful for collection of cord blood stem cells, which is a common practice in current medicine.
Generation of neural precursor cell lines
Patent Number: 5580777This patent covers neural stem cells that have been immortalized with c-myc or n-myc. These cells are useful not only for in vitro study and drug discovery, but also for therapy if differentiated properly so as to not possess malignant potential. The owner of the patent, Amrad, possesses numerous powerful patents in the area of stem cells.
Derivation of pluripotential embryonic cell lines from ungulate species
Patent Number: 6436701This patent covers methods of generating stem cells, embryonic stem cells from ungulate species. This technology may be useful not only for veterinary applications, but also for generating large quantities of cytoplasm with "dedifferentiating" ability that may be used for various regenerative purposes in humans...many of the cytoplasmic factors in embryonic stem cells that induce...
Method of freezing cells and cell-like materials
Patent Number: 6007978This patent covers methods of freeze-drying various cells, including stem cells.