Class: Extraction/Preservation (156)
Isolation of inner cell mass for the establishment of human embryonic stem cell (hESC) lines
Patent Number: 7,294,508Although the WARF/Geron patents have attracted much attention in recent history, many forget about the large embryonic stem cell patent portfolios that are being issued to institutions in countries such as Israel and India. The current patent, issued to the Indian stem cell giant Reliance, covers a method of generating embryonic stem cells that is significantly...
In vitro production of haploid germ cells
Patent Number: 6872569This patent teaches how to generate sperm in vitro through the use of sertoli cells and undifferentiated diploid germ cells. It is useful not only for infertility applications, but also for various veterinary purposes.
Pancreatic progenitor 1 gene and its uses
Patent Number: 6541251This patent teaches ways of identifying pancreatic stem cells by assessing expression of the gene which encodes pancreatic progenitor-1.
Isolation of neural stem cells using gangliosides and other surface markers
Patent Number: 7,419,825This patent covers a method of isolating neural stem cells by the surface marker CD15. This protein is found on neutrophils and other immune cells, known more for its adhesion functions and sugar-binding activity. Previously another patent (US # 7,182,946) touched upon the utility of this marker for purification of neural stem cells.
The patent...
System and method for processing bone marrow
Patent Number: 7008394Bone marrow transplants, as well as other bone marrow applications represent by far the largest use of stem cells in medicine. The process of harvesting bone marrow may be complicated and prone to contamination. Since bone marrow harvest is a painful and almost traumatic procedure, contamination of a bone marrow graft during harvest could be disasterous. The current invention teaches the use...
Method of isolating human neuroepithelial precursor cells from human fetal tissue
Patent Number: 6852532This patent teaches methods of extracting and purifying neuroepithelial precursor cells that can differentiate into a variety of neurological tissue and be useful for regenerative medicine. The patent essentially teaches to deplete cells expressing the markers A2B5, NG2 and eNCAM, so that approximately half of the purified cells are positive for
Method for producing a population of homozygous stem cells having a pre-selected immunotype and/or genotype, cells suitable for transplant derived therefrom, and materials and methods using same
Patent Number: 7030292This invention teaches how to generate a "cell bank" of embryonic stem cells that are homozygous at HLA. Theoretically, the inventors suggest..."that a few hundred stem cell lines that are homozygous for different haplotypes will be sufficient to match a majority of the human population. This number is tremendously smaller in contrast to the number of...
Cell surface expressed marker of pluripotency
Patent Number: 7,226,994This patent covers the composition of matter for two markers that are widely used for detecting germ cells. The markers being Fragilis and Stella. These are found also in embryonic stem cells and primordial germ cells. The patent is useful for development of laboratory reagents, as well as clinically developing methods of isolating specific cell populations.
Isolating cells expressing secreted proteins
Patent Number: 6919183This patent teaches ways of extracting cells from a population based on expression of markers that were either introduced or naturally expressed in the cell. The patent may be useful for pulling out differentiated cells from stem cell heterogenous populations. A method of detecting and/or isolating a eukaryotic cell that produces a secreted protein of interest (POI), comprising: (a...
Container for biological products requiring cellular stasis
Patent Number: 6773425This patent discloses various vessels and uses thereof that can be used to store stem cells and other biological products during transportation.