Class: Administration (73)
Nerve guidance channel containing bioartificial three-dimensional hydrogel extracellular matrix derivatized with cell adhesive peptide fragment
Patent Number: 5834029This patent teaches ways of generating in vitro channels in which nerves can be grown. These channels can then be administered in vivo for the treatment of neurodegenerative diseases.
Method for implanting encapsulated cells in a host
Patent Number: 5550050Microencapsulation allows delivery of immunologically incompatible cells to a recipient. The technology of microencapsulation has been used clinically for a variety of uses, including administration of cell therapy ranging from neurons to islets. The use of embryonic stem cells may require encapsulation so has to not only overcome the allogeneic barriers, but also to prevent growth and...
Compositions and methods for delivery of agents for neuronal regeneration and survival
Patent Number: 6551618This patent covers a matrix that is embedded with genes that stimulate stem cell expansion and/or differentiation. The matrix can be administered alone or in combination with stem cells.
Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products
Patent Number: 6960351One of the main drawbacks of stem cell therapy, or any cell therapy for that matter is that it is important to avoid the issue of immunological rejection. This is why numerous scientists are using autologous stem cells. Unfortunately, there is no such thing as autologous embryonic stem cells. Additionally, the ability to use allogeneic stem cells without rejection would allow for the...
Implantable biocompatible immunoisolatory vehicle for the delivery of selected therapeutic products
Patent Number: 6322804This patent provides methods of encapsulating cells so that they will not be rejected by the recipient immune system. Encapsulation devices such as this should be considered not only for the protection of the cells that are administered, but also for protection of the host from the cells. For example, lets say that embryonic stem cells are administered into a degenerating organ for the...
Implantable biocompatable immunoisolatory vehicle for delivery of selected therapeutic products
Patent Number: 6083523This patent covers a device that is implantable, and explantable, that can be used for administration of stem cells so that they will not be rejected by the host immune system. It will be interesting to use such devices with embryonic stem cells so as to allow the embryonic stem cells to secrete soluble factors in vivo that hopefully will possess rejuvenating ability.
Methods for making immunoisolatory implantable vehicles with a biocompatiable jacket and a biocompatible matrix core
Patent Number: 5834001This patent teaches ways of generating devices that contain cells or stem cells that can be implanted without fear of immune mediated rejection.
Methods for coextruding immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core
Patent Number: 5800829This patent provides a method of isolating cells from the immune system through encapsulation. Specific means of generating this implantable device, and use with stem cells, as well as other populations of cells is disclosed.
Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products
Patent Number: 5800828This patent teaches ways of growing cells in vivo in an environment that is protected from immunological attack. Specific ways of encapsulating cells, including stem cells, and their progeny are described. This patent is useful, in one embodiment, for the treatment of diabetes with artificially generated islets.
Therapeutic delivery compositions and methods of use thereof
Patent Number: 6933286The introduction of nucleic acids into cells is a difficult task that has significantly hampered gene therapy. This patent discloses a novel method of getting nucleic acids into cells. The patent has 2 independent claims. The first covers a composition of nucleic acid sequences or one or more triplex DNA compounds, and a nonionic block copolymer. The second...