Class: Administration (73)
Method of producing a mouse suitable for the engraftment, differentiation and proliferation of heterologous cells, mouse produced by this method and use of the mouse
Patent Number: 7,145,055The use of immunodeficient animals in stem cell research is very important since most researchers are interested in the in vivo activities of human stem cells without having to actually perform clinical trials.
The solution to this has been the use of animal strains that are either genetically immune deficient, or induced to be immune deficient. Previously the
Method to determine an engrafting cell dose of hematopoietic stem cell transplant units
Patent Number: 6852534At first glance this patent seems extremely simple and maybe even obvious. Essentially it teaches the use of counting of leukocytes from a hematopoietic stem cell graft so has to know how many cells to transplant for hematopoietic reconstitution. The invention is however very important in areas like cord blood stem cell transplants where it is very difficult to actually quantify the...
Delivery device for biological composites and method of preparation thereof
Patent Number: 6736799This patent covers a device for administration of biological matrices that can be co-implanted with stem cells for regenerative purposes.
Cardiac function comprising implantation of embryonic stem cell in which differentiation has been initiated
Patent Number: 6534052This patent teaches how to administer embryonic stem cells, and differentiated cells thereof, into the area of infarcted myocardium so as to prevent future heart failure.
Plasma-derived fibrin-based matrices and tissue
Patent Number: 6787357This patent provides matrices that can be generated easily in GMP conditions, and can be administered in combination with various stem cells for therapeutic benefits. Cytokines and other growth factors may also be administered with the stem cells into the matrix to either induce local proliferation, or to chemoattract endogenous stem cells.
Composition for delivery of hematopoietic growth factor
Patent Number: 6875441This patent teaches ways of formulating G-CSF so as to have better pharmacological properties. Specifically the patent is trying to address the problem of: "...administration of hematopoietic growth factors such as G-CSF, GM-CSF, SCF and Flt3-L, requires multiple daily injections. This, in turn leads to another common disadvantage of current injectable therapies... Heart failure has been one of the main areas of stem cell research. Specifically, stem cells have previously been used clinically both for treatment of immediate post myocardial infarction (primarily to inhibit scar tissue and subsequent remodelling), as well as in patients with cardiac degeneration in absense of a myocardial infarct.
The current patent is very interesting since it claims... This patent covers compositions of matter that can be used to deliver proteins to tissue. The matrices described in this patent can be seeded with cells for delivery of stem cells together with the therapeutic protein. In some embodiements of the patent the therapeutic protein can be an antibody, a growth factor, or a cytokine. This patent provides a medical device that can be utilized for administration of stem cells to localized areas of need using a catheter-based system. This patent teaches various forms of hyaloronic acid that may be administered in combination with stem cells for localization and better function of the stem cell. This patent is interesting in light of US patent application # 20060069064 which teaches "Methods for facilitating recovery of functions of endogenous or implanted or transplanted stem cells using hyaluronic acid"
Combination growth factor therapy and cell therapy for treatment of acute and chronic heart disease
Patent Number: 7,166,280
Delivery of therapeutic biologicals from implantable tissue matrices
Patent Number: 6692738
Cell delivery catheter and method
Patent Number: 6599274
Injectable hyaluronic acid derivative with pharmaceuticals/cells
Patent Number: 6699471