Patents (1436 Stem Cell Patents)

Class: 3D Culture/Scaffold (92)

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Methods for treating disease and forming a supplemented fibrin matrix

Patent Number: 7,208,179

The current patent covers various compositions of matter for manufacturing tissue sealants. The sealants covered contain various growth factors, either recombinantly produced and added, or added through activation of cells. The sealants described are potentially synergistic with stem cells for acceleration of wound healing.

Inventors: Drohan; William N. (Springfield, VA), MacPhee; Martin James (Gaithersburg, MD), Hollinger; Jeffrey O. (Gibsonia, PA)
Assignee: The American National Red Cross (Rockville, MD)
Date of First Priority Issue: Tuesday November 27th, 1990

Process and media for the growth of human cornea and gingiva

Patent Number: 5912175

This patent teaches how to grow specialized epithelial structures from stem cells such as cornea, gingiva, and ureters. Specific tissue culture conditions and media are provided for growing the stem cells and inducing their differentiation into the desired tissue.

Inventor: Wille, Jr., John J. (Trenton, NJ)
Assignee: Hy-Gene, Inc. (Ventura, CA)
Date of First Priority Issue: Sunday January 21st, 1990

Matrix for tissue engineering formed of a hyaluronic acid ester and hydrolyzed collagen

Patent Number: 6737072

This patent covers a matrix that is made of hyaluronic acid and hydrolyzed collagen, that can be used as a scaffold for in vitro three dimensional tissue generation, or can be seeded with stem cells and implanted in vivo.

Inventors: Angele, Peter (Regensburg, DE); Kujat, Richard (Pettendorf, DE)
Assignee: Nerlich, Michael (Pentling, DE)
Date of First Priority Issue: Saturday December 3rd, 1988

Media compositions for three-dimensional mammalian tissue growth under microgravity culture conditions

Patent Number: 5846807

This patent describes ways of growing tissue in space or under microgravity conditions. This patent could be used not only for generation of medically important implants, but also for production of various artificial meats and foods for astronauts to eat while in space.

Inventor: Goodwin, Thomas J. (Friendswood, TX)
Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space Administration (Washington, DC)
Date of First Priority Issue: Thursday June 30th, 1988

Method for producing non-neoplastic, three dimensional, mammalian tissue and cell aggregates under microgravity culture conditions and the products produced therefrom

Patent Number: 5496722

This patent teaches the generation of three dimensional tissues through culture under microgravity conditions. This patent discloses several culture conditions, as well as scaffolds, that can be utilized for the generation of the three dimensional organ or organoid structure.

Inventors: Goodwin, Thomas J. (Friendswood, TX); Wolf, David A. (Houston, TX); Spaulding, Glenn F. (Houston, TX); Prewett, Tacey L. (Friendswood, TX)
Assignee: The United States of America as represented by the Administrator of the (Washington, DC)
Date of First Priority Issue: Thursday June 30th, 1988

Three-dimensional culture of pancreatic parenchymal cells cultured living stromal tissue prepared in vitro

Patent Number: 6022743

This patent teaches the three dimensional generation of artificial pancreatic grafts using a proprietary culture system that is described in detail.

Inventors: Naughton, Gail K. (Del Mar, CA); Naughton, Brian A. (El Cajon, CA)
Assignee: Advanced Tissue Sciences, Inc. (La Jolla, CA)
Date of First Priority Issue: Friday April 18th, 1986

Three-dimensional stromal tissue cultures

Patent Number: 5962325

This patent teaches how to generate three dimensional cultures of stem cells through the use of special metrices and TGF beta. The three dimensional cultures can be generated using a variety of stem cells including mesenchymal stem cells. The mesenchymal stem cells may be extracted from bone marrow, cord blood or other sources.

Inventors: Naughton, Gail K. (La Jolla, CA); Naughton, Brian A. (El Cajon, CA)
Assignee: Advanced Tissue Sciences, Inc. (La Jolla, CA)
Date of First Priority Issue: Friday April 18th, 1986

Three-dimensional bone marrow cell and tissue culture system

Patent Number: 5541107

In this patent regarding bone marrow stem cell culture, Advanced Tissue Sciences continues their tour de force in three dimensional culture IP, through covering the use of three dimensional cultures for expanding bone marrow stem cells. Specifically, the patent teaches that stromal cells and a three dimensional matrix can be used for expansion of hematopoietic...

Inventors: Naughton, Gail K. (Groton, VT); Naughton, Brian A. (Groton, VT)
Assignee: Advanced Tissue Sciences, Inc. (La Jolla, CA)
Date of First Priority Issue: Friday April 18th, 1986

Three-dimensional pancreatic cell and tissue culture system

Patent Number: 5516681

This patent teaches the use of stromal cells to support growth, proliferation, and differentiation of islet-like pancreatic structures after addition of pancreatic acinar cells to the culture. This technology can be a great basis for the numerous other stem cell technologies currrently available for islet regeneration.

Inventors: Naughton, Gail K. (Groton, VT); Naughton, Brian A. (Groton, VT)
Assignee: Advanced Tissue Sciences, Inc. (La Jolla, CA)
Date of First Priority Issue: Friday April 18th, 1986

Three-dimensional kidney cell and tissue culture system

Patent Number: 5516680

This patent teaches the generation of artificial kidneys through culturing of various cells that comprise the functional kidney in a three dimensional stromal preparation. The patent may be used not only for addition of kidney stem cells, but can incorporate various types of adult and embryonic stem cells for generation of "younger" kidneys.

Inventors: Naughton, Gail K. (Groton, VT); Naughton, Brian A. (Groton, VT)
Assignee: Advanced Tissue Sciences, Inc. (La Jolla, CA)
Date of First Priority Issue: Friday April 18th, 1986

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