Patents (1436 Stem Cell Patents)

Class: 3D Culture/Scaffold (92)

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Resorbable extracellular matrix for reconstruction of cartilage

Patent Number: 7,208,177

The current patent covers a matrix that is useful for treatment of cartilage injuries. The matrix disclosed is resorbable at a controlled rate and contains collagen II either from autologous, allogeneic, or xenogeneic sources. Specific pore sizes and additives are claimed. The patent is useful for parties seeking methods of introducing cells or growth factors to accelerate cartilage...

Inventors: Geistlich; Peter (Stansstad, CH), Schloesser; Lothar (Darmstadt, DE)
Assignee: Ed. Geistlich Soehne AG fuer Chemische Industrie (Wolhusen, CH)
Date of First Priority Issue: Wednesday February 22nd, 1995

Bioartificial extracellular matrix containing hydrogel matrix derivatized with cell adhesive peptide fragment

Patent Number: 6156572

This patent provides novel compositions of matter that are useful for growing stem cells and neurons derived thereof for the purpose of implantation into the host. Specific matrices are provided.

Inventors: Bellamkonda, Ravi (Boston, MA); Ranieri, John P. (Lausanne, CH); Aebischer, Patrick (Lutry, CH)
Assignee: Neurotech S.A. (Evry, FR)
Date of First Priority Issue: Wednesday July 20th, 1994

Control of cell growth in a bioartificial organ with extracellular matrix coated microcarriers

Patent Number: 5858747

This patent covers several means of growing stem cells and their derivatives, as well as generating scaffolds and implantable means that protect the stem cells from the immunological reaction of the host.

Inventors: Schinstine, Malcolm (Ben Salem, PA); Shoichet, Molly S. (Toronto, CA); Gentile, Frank T. (Warwick, RI); Hammang, Joseph P. (Barrington, RI); Holland, Laura M. (Horsham, PA); Cain, Brian M. (Everett, MA); Doherty, Edward J. (Mansfield, MA); Winn, Shelley R
Assignee: CytoTherapeutics, Inc.
Date of First Priority Issue: Wednesday July 20th, 1994

Method for controlling proliferation and differentiation of cells encapsulated within bioartificial organs

Patent Number: 5795790

This patent teaches the use of UV irradiation in order to render encapsulated cells mitotically inactive, but still metabolically active. This patent is useful for the generation of grafts that are implantable, for example an artificial pancreas.

Inventors: Schinstine, Malcolm (Ben Salem, PA); Shoichet, Molly S. (Toronto, CA); Gentile, Frank T. (Warwick, RI); Hammang, Joseph P. (Barrington, RI); Holland, Laura M. (Horsham, PA); Cain, Brian M. (Everett, MA); Doherty, Edward J. (Mansfield, MA); Winn, Shelley R
Assignee: Cytotherapeutics, Inc. (Lincoln, RI)
Date of First Priority Issue: Wednesday July 20th, 1994

Biomatrix for soft tissue regeneration using mesenchymal stem cells

Patent Number: 6174333

This patent covers implantable agents that can be administered together with mesenchymal stem cells for the purpose of creating or repairing various tissues.

Inventors: Kadiyala, Sudhakar (Baltimore, MD); Caplan, Arnold I. (Cleveland Heights, OH); Fink, David J. (Shaker Heights, OH); Young, Randall G. (Ellicott City, MD)
Assignee: Osiris Therapeutics, Inc. (Baltimore, MD); Case Western Reserve University (Cleveland, OH)
Date of First Priority Issue: Monday June 6th, 1994

Manufacture of autogenous replacement body parts

Patent Number: 6110482

This patent teaches how to make artificial joints using stem cells and various devices and systems.

Inventors: Khouri, Roger K. (St. Louis, MI); Sampath, Kuber T. (Medway, MA); Rueger, David C. (Hopkinton, MA)
Assignee: Styker Corporation (Kalamazoo, MI)
Date of First Priority Issue: Friday June 3rd, 1994

Method and construct for producing graft tissue from an extracellular matrix

Patent Number: 6398819

This patent teaches ways of decellularizing tissue, including xenogeneic tissue, so that it may be used as a scaffold to be seeded with human stem cells, and then the stem cells plus tissue scaffold are implanted into the human as an artificial composite tissue.

Inventor: Bell, Eugene (Boston, MA)
Assignee: TEI Biosciences, Inc. (Boston, MA)
Date of First Priority Issue: Friday August 7th, 1992

Method and construct for producing graft tissue from an extracellular matrix

Patent Number: 5800537

This patent teaches how to decellularize various tissues and to use the remnants as a scaffold for seeding of stem cells. This patent is useful for tissue engineering of varous organs and anatomical structures.

Inventor: Bell, Eugene (Boston, MA)
Assignee: Tissue Engineering, Inc. (Boston, MA)
Date of First Priority Issue: Friday August 7th, 1992

Methods and compositions for isolation and growth of kidney tubule stem cells, in vitro kidney tubulogenesis and ex vivo construction of renal tubules

Patent Number: 6060270

This patent teaches how to grow kidney tubules from renal stem cells, and how to use these for making a hollow fiber filter that resembles an artificial kidney.

Inventor: Humes, H. David (Ann Arbor, MI)
Assignee: The University of Michigan (Ann Arbor, MI)
Date of First Priority Issue: Monday March 2nd, 1992

Methods and compositions of a bioartificial kidney suitable for use in vivo or ex vivo

Patent Number: 5549674

This patent covers an artificial kidney system designed in a manner so as to combine hollow fiber technology with living, fresh endothelial cells. This patent does mention that in some embodiments stem cells may be used for providing the necessary cells. Various artificial kidneys have been designed and the author of this patent has actually been involved in their clinical development...

Inventors: Humes, H. David (Ann Arbor, MI); Cieslinski, Deborah A. (Ann Arbor, MI)
Assignee: The Regents of The University of Michigan (Ann Arbor, MI)
Date of First Priority Issue: Monday March 2nd, 1992

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