Class: Mobilization (30)
Methods to mobilize progenitor/stem cells
Patent Number: 7,169,750The reason why bone marrow cells home into the bone after intravenous administration is because a continuous production of Stromal Derived Factor-1 (SDF-1) by the bone marrow stromal compartments. The gradient of SDF-1 is also retains the early CD34+ bone marrow hematopoietic stem cells in the bone marrow. The current patent covers...
Methods and compositions for modulating sphingosine-1-phosphate (S1P) receptor activity
Patent Number: 7,241,812It is known that Sphingosine-1-phosphate mediates migration of mesenchymal stem cells. However, there are numerous receptors by which the effects of sphingosine-1-phosphate are mediated. While the sphingosine-1-phosphate receptor 1 is associated with migration, other activation of other receptors (such as sphingosine-1-phosphate...
G-CSF therapy as an adjunct to reperfusion therapy in the treatment of acute myocardial infarction
Patent Number: 7,220,407Subsequent to myocardial infarction, cells of the injured myocardium release a variety of cytokines and mediators that are involved in mobilizing endogenous bone marrow stem cells and inducing their migration to the area of myocardial injury. One cytokine released is G-CSF, which in addition to possessing hematopoietic functions also is a great mobilizer of stem cells. In the current...
Mobilization of hematopoietic cells
Patent Number: 7,417,026Mobilization of stem cells is a very hot area these days. At face value, mobilization is important for donors of hematopoietic stem cells since it alleviates the need for performing puncture of the iliac crest of healthy people who are donating bone marrow. Currently, mobilization is performed by administering to the donor G-CSF (neupogen), which activates a cascade of enzymes and...
Hematopoietic stem cells treated by in vitro fucosylation and methods of use
Patent Number: 7,332,334On of the interesting methods of manipulating stem cells is to increase their ability to “go where they are suppose to”. For example, it is known that when bone marrow or cord blood hematopoietic stem cells are injected intravenously into an irradiated recipient, the cells selectively home to the bone marrow and if enough cells migrate appropriately, hematopoietic reconstitution...
Chemokine analogs for the treatment of human disease
Patent Number: 7,091,310This patent is useful for stem cell mobilization, stem cell homing, as well as a variety of other applications involving various chemokines. Specifically, the invention covers peptides that antagonize or agonize receptors for IL-8, IP-10, MIP-1 alpha., MCP-1, RANTES, I-309, and CCL28. Inventors: Merzouk, Ahmed (Richmond, CA); Wong, Donald (Vancouver, CA); Salari, Hassan (Delta, CA)
Regulation of cytotrophoblast cell differentiation and cell migration
Patent Number: 7,244,707Although this patent describes modulation of stem cell migration in the specification, the claims are restricted to the regulation of placental size. Specifically, the patent claims the use of IGF-2 to augment "placental growth, placental function, placental development and placental differentiation" in a mammal. The inventors appear to be the first to discover...
Parathyroid hormone receptor activation and hematopoietic progenitor cell expansion
Patent Number: 7,429,383Mobilization of stem cells is big money. For example, the company Anormed was bought by Genzyme for more than half a billion dollars because of its late-phase compound, a CXCR4 antagonist which mobilizes study cells. Why would one be interested in mobilizing stem cells out of the bone marrow? Firstly, this is used instead of drilling holes in the...
Methods and compositions for directing cells to target organs
Patent Number: 7,282,222This patent covers the use of various carbohydrate presenting molecules for increasing amount of stem cell homing to tissue where stem cell migration is desired. Specific molecules that attract the stem cells which are covered include asialoorosomucoid and orosomucoid. This patent could be used to not only augment currented CD34 stem cell therapy efficacy but...
Methods to mobilize progenitor/stem cells
Patent Number: 6987102Hematopoietic stem cells stay in the bone marrow due in part to secretion of SDF-1 by bone marrow stromal cells. The chemotactic gradient of SDF-1 is also what causes hematopoietic stem cells to home to the bone marrow of the recipient after a bone marrow transplant. This invention covers some antagonists of the receptor for