Patents
Homogeneous mammalian hematopoietic stem cell composition
Patent Number: 5087570This patent covers the use of the stem cell antigen (SCA-1) for determination of murine hematopoieitic stem cells. The patent has 1 independent claim that covers "A cell composition consisting essentially of as the cellular population viable murine hematopoietic Sca-1+ stem cells from a genetically identical or congenic source."
Inventors: Weissman, Irving L. (Stanford, CA); Spangrude, Gerald J. (N/A); N/A (VIC 3050, AU); Muller-Sieburg, Christa (San Diego, CA); Heimfeld, Shelly
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Wednesday October 5th, 1988
Human hematopoietic stem cell
Patent Number: 5061620This is another patent on the hematopoietic stem cell. It is filed later than Civin's, that is why this is an interesting patent. Furthermore it actually mention's Civin's patent "U.S. Pat. No. 4,714,680 describes a composition comprising human stem cells. " In any case, this current patent has 3 independent claims. The first covers "A cellular composition comprising human...
Inventors: Tsukamoto, Ann (Palo Alto, CA); Baum, Charles M. (Menlo Park, CA); Aihara, Yukoh (Hiratsuka, JP); Weissman, Irving (Palo Alto, CA)
Assignee: SyStemix, Inc. (Palo Alto, CA)
Date of First Priority Issue: Friday March 30th, 1990
Human stem cells and monoclonal antibodies
Patent Number: 5035994This patent futher strengthens Civin's claim (no pun intended) on the hematopoietic stem cell. The first independent claim covers "A method of isolating a population of human cells containing pluripotent lympho-hematopoletic stem cells" through ANY ANTIBODY that bind to the antigen that is recognized by the antibody deposited with ATCC under Accession No. HB-8483. The second...
Inventor: Civin, Curt I. (Baltimore, MD)
Assignee: The Johns Hopkins University (Baltimore, MD)
Date of First Priority Issue: Monday January 5th, 1987
Potentiation of erythropoiesis
Patent Number: 5032507This patent covers the discover that follicle stimulating hormone releasing protein (FRP) can potentiate the activity of erythropoitin in terms of induce erythropoiesis. The patent covers this concept from three perspectives in its three independent claims. The first perspective is "a method for determining the erythrodifferentiation-potentiating capacity of hematopoietic stem...
Inventors: Yu, John (San Diego, CA); Yu, Alice L. (San Diego, CA); Vaughan, Joan (San Diego, CA); Rivier, Jean E. F. (La Jolla, CA); Vale, Jr., Wylie W. (La Jolla, CA)
Assignee: The Salk Institute for Biological Studies (San Diego, CA); The Regents of the University of California (Berkeley, CA); Scripps Clinic and Research Foundation (La Jolla, CA)
Date of First Priority Issue: Sunday December 13th, 1987
Gene transfer using transformed, neodetermined, embryonic cells
Patent Number: 5032407This patent teaches that embryonic yolk sac, midbrain, and forbrain cells may be gene transfected with a useful gene and utilized as a vector for delivery of the gene to an area of need.
Inventors: Wagner, Thomas E. (Athens, OH); Reed, Michael A. (Athens, OH); Corn, Barbara J. (Athens, OH)
Assignee: Ohio University Edison Animal Biotechnology Center (Athens, OH)
Date of First Priority Issue: Friday January 16th, 1987
Preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood
Patent Number: 5004681This patent covers freezing of cord blood for future use. The patent has one independent claim covering the composition of a cryopreservant, together with viable fetal or neonatal hematopoietic cells. PharmaStem is the successor to Biocyte Corporation, the assignee of this patent. This patent, together with patents 5 192 553, 6 461 645, 6 569 427 and 6 605 275 are used by Pharmastem to...
Inventors: Boyse, Edward A. (New York, NY); Broxmeyer, Hal E. (Indianapolis, IN); Douglas, Gordon W. (New York, NY)
Assignee: Biocyte Corporation (New York, NY)
Date of First Priority Issue: Friday December 11th, 1987
Bone marrow suppressing agents
Patent Number: 4976950This patent has 2 independent claims, the first covering a method of suppressing the bone marrow, the second covering a sterile injectable capable of suppressing the bone marrow. The method by which this patent teaches to suppress the bone marrow is through administration of a sterile composition containing the radionuclide Yttrium-90 complexed with at least one macrocycle aminophosphonic acid...
Inventors: Simon, Jaime (Angleton, TX); Garlich, Joseph R. (Lake Jackson, TX); Wilson, David A. (Richwood, TX); McMillan, Kenneth (Richwood, TX)
Assignee: The Dow Chemical Company (Midland, MI)
Date of First Priority Issue: Monday December 19th, 1988
Human stem cells and monoclonal antibodies
Patent Number: 4965204This patent is a division of application Ser.No. 670,740, filed Feb.6, 1984 which issued on Dec. 22, 1987 as U.S. Pat. No. 4,714,680 and was described below. This patent is similar to 4,714,680 with the exception that the one independent claim in this patent covers in more detail the antibody which is now known to recognize CD34. Essentially, this is the first time that an antibody has been...
Inventor: Civin, Curt I. (Baltimore, MD)
Assignee: The Johns Hopkins University (Baltimore, MD)
Date of First Priority Issue: Tuesday December 22nd, 1987
Cellular enhancer for expressing genes in undifferentiated stem cells
Patent Number: 4959313This patent covers a specific DNA enhancer sequence that is activated uniquely in embryonic stem cells. Such an enhancer is useful for numerous genetic engineering techniques, as well as, I believe, for generation of transgenic animals.
Inventor: Taketo, Makoto (Bar Harbor, ME)
Assignee: The Jackson Laboratory (Bar Harbor, ME)
Date of First Priority Issue: Monday June 22nd, 1987
Method for the stimulation of bone marrow cells
Patent Number: 4946437This patent is a novel way to expand bone marrow cells ex vivo through contacting the bone marrow with a family of compounds. The single issued independent claim covers "A method for the transplantation of bone marrow cells" and the method involved contacting with a specific family of compounds. The first dependent claim states one member of this family of compounds as being...
Inventors: Sredni, Benjamin (Beni Brak, IL); Albeck, Michael (Ramat Gan, IL)
Assignee: Bar-Ilan University (Ramat-Gan, IL)
Date of First Priority Issue: Friday February 12th, 1988