Patents
Polypeptide derivatives of human granulocyte colony stimulating factor
Patent Number: 5362853G-CSF is used clinically for stimulation of neutrophil production in pateints that have taken chemotherapy, radiation therapy (in some cases), as well as post bone marrow tranplant. This patent covers peptide derivatives of G-CSF that are useful for stimulation of hematopoiesis. It may be interesting to use this patent to compete with currently used G-CSF formulations.
Inventors: Kuga, Tetsuro (Yamaguchi, JP); Miyaji, Hiromasa (Tokyo, JP); Sato, Moriyuki (Tokyo, JP); Okabe, Masami (Shizuoka, JP); Morimoto, Makoto (Shizuoka, JP); Itoh, Seiga (Kanagawa, JP); Yamasaki, Motoo (Tokyo, JP); Yokoo, Yoshiharu (Kanagawa, JP); Yamaguchi, Ka
Assignee: Kyowa Hakko Kogyo Co., Ltd. (Tokyo, JP)
Date of First Priority Issue: Tuesday December 23rd, 1986
Methods for stimulating hematopoietic progenitors using hepatocyte growth factor and lymphokines
Patent Number: 5362716This patent covers stimulation of hematopoietic stem cells by administration of hepatocyte growth factor with either IL-3 or GM-CSF. Hepatocyte growth factor has been used clinically in a variety of situations including to stimulate angiogenesis. It may be interesting, in light of the claimed pro-hematopoietic stem cell activity of hepatocyte growth factor, to try using this cytokine...
Inventors: Kmiecik, Thomas E. (Frederick, MD); Vande Woude, George F. (Berryville, VA)
Assignee: The United States of America as represented by the Department of Health (Washington, DC)
Date of First Priority Issue: Wednesday December 27th, 1989
Stimulation of stem cell growth by the bryostatins
Patent Number: 5358711Bryostatin is a drug derived from a type of symbiont bacteria. Although bryostatin has been used in clinical trials for oncology, results have not been excellent. This patent teaches that bryostatin and various derivatives thereof are useful for stimulation of hematopoietic stem cell proliferation. It will be interesting to see if bryostatin works on stimulating stem cell activity of other...
Inventors: May, W. Stratford (Baltimore, MD); Sensenbrenner, Lyle L. (Grosse Pointe Park, MI)
Assignee: Johns Hopkins University (Baltimore, MD)
Date of First Priority Issue: Monday November 23rd, 1987
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Conditioned medium useful for sustaining growth of colonic crypt cells
Patent Number: 5316937Colonic crypt cells are a population of self renewing stem cells that are depleted after radiation and in some situations chemotherapy due to their rapid basal proliferation. In this patent a method of stimulating crypt cell proliferation is disclosed through administration of a conditioned media. This patent may be useful for identifying the active ingredient in the conditioned media and...
Inventors: Whitehead, R. H. (Victoria, AU); Burgess, Anthony (Victoria, AU); Zhang, Hui-Hua (Victoria, AU)
Assignee: Ludwig Institute for Cancer Research (NY)
Date of First Priority Issue: Monday March 16th, 1992
Method for protecting bone marrow against chemotherapeutic drugs using transforming growth factor beta 1
Patent Number: 5278145TGF-beta is an inhibitor of hematopoietic stem cell proliferation. It is known that autologous TGF-b is involved in keeping stem cells in a quiescent G0 state. This patent teaches the systemic administration of TGF-b before administration of a chemotherapeutic drug so as to protect the stem cells from damage.
Inventors: Keller, Jonathan R. (Frederick, MD); Ruscetti, Francis W. (Rockville, MD); Wiltrout, Robert (Frederick, MD)
Assignee: The United States of America as represented by the Department of Health (Washington, DC)
Date of First Priority Issue: Thursday June 29th, 1989
Hemolymphopoietic growth factors, process for purifying and producing hemolymphopoietic growth factors and pharmaceutical compositions made therefrom
Patent Number: 5264418This patent claims a hematopoietic stem cell growth factor called HLGF. This factor seems to synergize with other stem cell stimulator factors such as G-CSF, GM-CSF, and IL-3. The modern identify of this factor will be of interest since it may be developed into a therapeutic.
Inventors: Quesenberry, Peter J. (Charlottesville, VA); McNiece, Ian K. (Charlottesville, VA)
Assignee: The University of Virginia Alumni Patents Foundation (Charlottesville, VA)
Date of First Priority Issue: Friday January 24th, 1986
Uteroferrin and rose proteins for stimulating hematopoietic cells
Patent Number: 5258367This patent teaches that uteroferrin (placental Type V acid phosphatase) is a stimulator of hematopoietic stem cells. Uteroferrin is made during pregnancy and is associated with iron transport. The use of uteroferrin for hematopoiesis may be a potent new way of approaching the problem of neutropenia.
Inventors: Bazer, Fuller W. (Gainesville, FL); Gross, Samuel (Gainesville, FL)
Assignee: University of Florida (Gainesville, FL)
Date of First Priority Issue: Friday June 29th, 1990
Primitive cell colony stimulating factors and lymphohematopoietic progenitor cells
Patent Number: 5256560There are numerous stem cell types in the bone marrow. Specific stem cells of the hematopoietic lineage were originally identified as being CD34+. In this patent, a CD34-stem cell is claimed that produces growth factors capable of stimulating hematopoiesis. This patent may be a really great candidate for developing since at first appearance it does not seem to be under...
Inventors: Lawman, Michael J. P. (Gainsville, FL); Ohmann, Helle B. (Saskatchewan, CA); Attah-Poku, Samuel K. (Saskatchewan, CA); Heise-Qualtiere, Janette (Saskatchewan, CA)
Assignee: University of Saskatchewan (Saskatoon, CA)
Date of First Priority Issue: Friday October 7th, 1988
CD4.sup.+, latently HIV-1-infected hematopoietic progenitor cells
Patent Number: 5256534This patent covers a model of HIV infection. Specifically HIV infected stem cells of the hematopoietic type are infected and infection remains latent. HIV treatments may be assessed using this model of "stem cell" HIV infection.
Inventors: Butera, Salvatore T. (Stone Mountain, GA); Folks, Thomas M. (Lithonia, GA); Perez, Victor L. (Rio Piedras, PR)
Assignee: The United States of America as represented by the Department of Health (Washington, DC)
Date of First Priority Issue: Friday August 9th, 1991
Maturation of hemopoietic cells
Patent Number: 5246699This patent teaches a really interesting way of stimulating myelopoiesis by exposing myeloid precursor cells to a compound called IgE binding factor. Myeloid precursors are important for generation of neutrophils and therefore protecting from opportunistic diseases. Stimulation of myeloid cells by this approach may be useful for immune modulation as well, some papers suggest that myeloid...
Inventors: Debre, Patrice (Paris, FR); Mossalayi, Mohammad D. (Boussy St Antoine, FR)
Assignee: Ciba-Geigy Corporation (Ardsley, NY)
Date of First Priority Issue: Wednesday May 9th, 1990