Patents

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Serial nuclear transfer of ungulate embryos

Patent Number: 7,321,075
This patent covers a method of cloning in which the nucleus is transferred across generations. The first claim exemplifies the basis of what is covered, which is essentially "serial nuclear transfer" by a) taking a transgenic nucleus b) culturing the nucleus in an embryo c) splitting the embryoin into cells d) taking the nucleus from the cells and using it to insert into oocytes in order...

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Ependymal neural stem cells and method for their isolation

Patent Number: 7,320,872
Glia are the non-neuronal cells of the central nervous system. There are several types of glia. For example, microglia are generally hematopoietically derived cells similar to macrophages that are capable of phagocytosis and clearing local debris. Astrocytes are responsible for physically connecting the neurons to the vasculature feeding them. Astrocytes also regulate the ionic environment, as...

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Biological scaffolding material

Patent Number: 7,319,035
There are numerous patents issued on generation of scaffolds for the implantation of cells into a host in need of therapy. For example, Ethicon's patent 7,091,191 teaches the generation of hydrophobic polymers of hyaluronic acid that are superior to previous hyaluronic acid compositions since the the hydrophobicity extends the...

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Conformable tissue repair implant capable of injection delivery

Patent Number: 7,316,822
This patent covers an implantable matrix that includes: a) the matrix itself; b) live cells; and c) tissue fragments. The matrix itself is made of granules which are resorbable and bear a specific size. The tissue fragments include cartilage, meniscus, tendon, ligament, dermis, bone, fat, and combinations thereof. The overall mixture may be injected for treatment of a variety of degenerative...

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Cardiac stimulation system with delivery of conductive agent

Patent Number: 7,317,950
This patent covers a device that stimulates conductivity of electrical signals in the heart. Amongst the uses of the invention is to ensure proper biventricular septal pacing. The invention claims the use of various cells, including stem cells, for increasing certain conductivity connections.

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Polynucleotides encoding stem cell growth factor-like polypeptides

Patent Number: 7,317,099
This patent covers the composition for matter of a polypeptide capable of acting as a growth fractor for stem cells. Although the claims are primarily limited to composition of matter, the specification describes numerous uses including: 1). Gene therapy, 2). Transgenic animals, 3). Nutritional uses, 4). Stimulation of hematopoiesis, 5). Stimulation of tissue growth, 6). Immune modulation, 7...

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Amino thiol compounds and compositions for use in conjunction with cancer therapy

Patent Number: 7,314,959
One of the important areas of drug development is protecting stem cells and healthy tissue from the damaging effects of cytotoxic chemotherapy and radiation therapy. In fact, a "stem cell therapy" that has become a multi-billion dollar product is the use of G-CSF to stimulate hematopoietic recovery after cancer therapy or bone marrow transplantation. In fact, numerous patents have been filed for...

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Cysteine variants of erythropoietin

Patent Number: 7,314,921
This patent covers the composition of matter for specific variants of erythropoietin, the renal secreted hormone responsible for generation of erythrocyte differentiation from bone marrow hematopoietic stem cells. Specifically, the patent covers variants of the erythropoietin molecule in which the amino acid cysteine is substituted for amino acids that are not essential for erythropoietin binding...

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Insulin-secreting immortalized liver cell line modified by glucose sensitivity

Patent Number: 7,312,077
It has previously been demonstrated that rat hepatic cells can be coaxed into producing insulin by isolating the hepatic cells from an animal that was first primed with a hepatoxin, and subsequently exposing the isolated hepatic cells to high glucose concentrations. In the current patent a hepatic cell line that has been...

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Tissue matrices comprising placental stem cells, and methods of making the same

Patent Number: 7,311,904
The use of decellularized tissue as a scaffold onto which stem cells may be seeded has previously been patented. In the current patent the unique approach is taken that embryonic-like stem cells, as described in patent 7,311,905 are utilized to seed the decellularized...

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