Patents
High-throughput stem cell assay of hematopoietic stem and progenitor cell proliferation
Patent Number: 7,354,729This patent covers specific conditions for assessing ability of hematopoietic stem cells to proliferate or become metabolically active after exposure to a test agent in vitro. Essentially the patent is useful for the screening of small molecules using high throughput systems for identification of hematopoietic stem cell modulators.Specific hematopoietic stem cells covered in the patent...
Inventors: Rich; Ivan N. (Columbia, SC)
Assignee: HemoGenix, Inc. (Colorado Springs, CO)
Date of First Priority Issue: Monday January 29th, 2001
Musculo-skeletal implant having a bioactive gradient
Patent Number: 7,351,423It is known that stem cells migrate towards injured tissue in response to chemotactic gradients. For example the basal SDF-1 gradient made by bone marrow stromal cells is why it is possible to achieve hematopoietic reconstitution by injecting donor cells intravenously. Similarly, SDF-1 acts as a gradient to call stem cells into damaged myocardium after a...
Inventors: Kadiyala; Sudhakar (Newton, MA), Binette; Francois (Weymouth, MA), Coleman; Cynthia Marie (Brookline, MA), Kapur; Theresa Adams (Stoughton, MA)
Assignee: Depuy Spine, Inc. (Raynham, MA)
Date of First Priority Issue: Wednesday September 1st, 2004
Efficient nuclear transfer with primordial gametes
Patent Number: 7,351,876This patent covers a new method of cloning cows. Specifically, the patent teaches a method of making a cow blastocyst by - extracting a primordial gamete cell population from the cow fetus- using the nucleus of the primordial gamete cell as a nuclear donor for an enucleated oocyte- and activating the combination of the primordial gamete nucleus with the recipient enucleated oocyteAccording...
Inventors: Brem; Gottfried (Hilgertshause, DE), Durcova-Hills; Gabriela (Oberschlei.beta.heim, DE), Muller; Sigrid (Vienna, AT), Schernthaner; Wolfgang (Oberscheli.beta.heim, DE), Wenigerkind; Hendrik (Vienna, AT), Wolf; Eckhard (Vienna, AT), Zakhartchenko; Valeri (
Assignee: Agrobiogen GmbH Biotechnologie (Hilgertshausen, DE)
Date of First Priority Issue: Thursday September 12th, 2002
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Myocardial stimulation
Patent Number: 7,349,740The positive effects of stem cells in cardiac conditions is supported by many clinical trials. Efficacy has been demonstrated by both intracoronary administration, as well as intravenous administration of bone marrow and mesenchymal stem cells, respectively.In this patent, Medronics was granted some pretty far-reaching claims. This is a representative claim "A method comprising...
Inventors: Soykan; Orhan (Shoreview, MN), Maura; Donovan G. (St. Paul, MN)
Assignee: Medtronic, Inc. (Minneapolis, MN)
Date of First Priority Issue: Monday July 28th, 2003
Methods of treatment of hematopoietic disorders
Patent Number: 7,347,999This patent covers a "method of treating a mammal suffering from a hematopoietic disorder wherein bone marrow transplantation is required" through the administration of bone marrow cells and a bone matrix. The patent is interesting since it covers into only administration into the bone but also in sites outside of the bone. The patent covers various additives that can be used...
Inventors: Slavin; Shimon (Ein Kerem, 95744 Jerusalem, IL), Gurevitch; Olga (Jerusalem, IL), Kurkalli; Basan Gowda S. (Jerusalem, IL), Prigozhina; Tatyana (Rehovot, IL)
Assignee: Slavin Shimon (Jerusalem, IL)
Date of First Priority Issue: Monday March 5th, 2001
Antigen modified cancer cell vaccines for cancer therapy
Patent Number: 7,348,015This patent covers a way of "controlling or inhibiting blastoma cancer cell proliferation in a mammal" by vaccinating with tumor cells that express the Streptococcus pyogenes gene emm55. The natural function of emm55 appears to be in immune evasion of the complement system. Since tumor cells have mammalian complement inhibitory proteins, maybe the approach proposed by...
Inventors: Lawman; Michael J. P. (Tampa, FL), Lawman; Patricia D. (Tampa, FL)
Assignee: Morphogenesis, Inc. (Tampa, FL)
Date of First Priority Issue: Wednesday January 14th, 1998
Method for expansion of epithelial stem cells
Patent Number: 7,347,876Corneal transplants are performed as a result of chemical or inflammatory injury to the clear part of the eye. Efficacy of corneal transplantation is decreased when the limbal stem cells which produce corneal epithelium are damaged or defective. Accordingly, transplantation of limbal stem cells has been performed clinically. A report in 1999 documented...
Inventors: Tsai; Ray Jui-Fang (Taipei, TW)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Wednesday April 25th, 2001
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Sirtuin modulating compounds
Patent Number: 7,345,178This patent covers the composition of matter for novel compounds that are useful for modulation of sirtuins. Sirtuins are a class of proteins that act as histone deacetylase inhibitors. Why there is great interest in modulating these enzymes is because the SIR2 members of this family have been demonstrated to play a critical role in life extension associated with caloric restriction. This...
Inventors: Nunes; Joseph J. (Andover, MA), Milne; Jill (Brookline, MA), Bemis; Jean (Arlington, MA), Xie; Roger (Southborough, MA), Vu; Chi B. (Arlington, MA), Ng; Pui Yee (Boston, MA), Disch; Jeremy S. (Natick, MA)
Assignee: Sirtris Pharmaceuticals, Inc. (Cambridge, MA)
Date of First Priority Issue: Thursday August 4th, 2005
Methods of expanding stem and progenitor cells and expanded cell populations obtained thereby
Patent Number: 7,344,881This patent covers methods of expanding hematopoietic stem cells and their progenitors. The methods induce expansion but not differentiation of the cells. Essentially the patent teachs that expansion can be achieved by culture in media containing an "effective amount of TEPA-Cu chelate". TEPA stands for tetraethylenepentamine, which is a potent copper chelator. The inventors have...
Inventors: Peled; Tony (Mevaseret Zion, IL), Treves; Avi (Mevaseret Zion, IL), Rosen; Oren (Jerusalem, IL)
Assignee: Gamida Cell Ltd. (Jerusalem, IL)
Date of First Priority Issue: Friday January 25th, 2002
Myoblast therapy for cosmetic treatment
Patent Number: 7,341,719One of the regenerative cells of the muscle is the myoblast. These cells essentially act as muscle stem cells, having the ability to multiply after injury and form muscle by fusing with other myoblasts. Myoblasts are very practical for cell therapy since they may be easily extracted from autologous sources and grown in vitro. Additionally, there is some evidence that myoblasts, upon fusing to...
Inventors: Law; Peter K. (Memphis, TN)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Tuesday December 13th, 1994