Patents

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Medium for growing human embryonic stem cells

Patent Number: 7,297,539
One of the restrictions of tissue culture in general has been the need for fetal calf serum. No one has yet figured out what is the "magical mixture" of proteins and growth factors that allows fetal calf serum its properties to all for such effective growth of cells outside of the body. In fact, some other groups use horse serum, or cord...

Inventors: Mandalam; Ramkumar (Union City, CA), Xu; Chunhui (Cupertino, CA)

Assignee: Geron Corporation (Menlo Park, CA)

Date of First Priority Issue: Tuesday January 11th, 2000

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Process for producing nerve stem cells, motor neurons, and GABAergic neurons from embryonic stem cells

Patent Number: 7,294,510
This patent covers the generation of neurons through inducing embryonic stem cells to differentiate using the noggin protein and combinations of noggin with other factors. Noggin is an antagonist of bone morphogenic proteins and has been demonstrated to regulate numerous stem cell activities in vivo. The patent essentially teaches the use of noggin and ES cells for: - forming embryoid...

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Isolation of inner cell mass for the establishment of human embryonic stem cell (hESC) lines

Patent Number: 7,294,508
Although the WARF/Geron patents have attracted much attention in recent history, many forget about the large embryonic stem cell patent portfolios that are being issued to institutions in countries such as Israel and India. The current patent, issued to the Indian stem cell giant Reliance, covers a method of generating embryonic stem cells that is significantly different then those covered by...

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Methods and compositions to treat myocardial conditions

Patent Number: 7,294,334
Myocardial infarctions cause massive lose of cardiac muscle, as well as cause numerous electrophysiological dysfunctions that can immediately or in the long-term lead to death. The current patent has 2 independent claims that deal with this. The first one teaches the application of a pacing therapy in the infarct area together with the percutaneous administration of porcine "donor cells...

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Methods of using flt3-ligand in hematopoietic cell transplantation

Patent Number: 7,294,331
Flt3 ligand is a potent stimulator of hematopoietic stem cell proliferation. This cytokine has other effects as well, such as increasing the number of dendritic cells, particularly of the lyphoid phenotype. The current patent covers the use of Flt3 ligand in transplantation of hematopoietic stem cells. Particularly the administration of Flt3 ligand before introduction of hematopoietic...

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Genetic modification of male germ cells for generation of transgenic species and genetic therapies

Patent Number: 7,294,755
Usually transgenic animals are generated by ex vivo modification of female genetic materials and implantantion into a receptive recipient. In the current patent a different approach is taken to generation of transgenic or genetically modified animals. The patent covers the in vivo genetic modification of male gametes and subsequent mixture of the male genetic material with an unmodified female egg...

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Telomerase reverse transcriptase fragments and uses thereof

Patent Number: 7,294,708
Telomerase reverse transcriptase is an enzyme that transcribes the telomerase RNA component into telomeric DNA in order to replenish telomeric loss associated with cellular proliferation. The activity of telomerase is absent in most adult cells with the exception of stem cells and tumor cells. Accordingly, one possible method of blocking tumor cells is to inhibit their telomerase activity. Various...

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Growth factor therapy mobilization of stem cells into the peripheral blood

Patent Number: 7,291,597
This patent covers the use of inhalation therapy of cytokines (FGF-1,2 and VEGF) for mobilization of stem cells. The patent is similar to patent 7,288,521 which was discussed last week.

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Preparation of a cell concentrate from a physiological solution

Patent Number: 7,291,450
The use of bone marrow mononuclear cells as a source of stem cells has been widely described in numerous medical procedures ranging from stimulation of angiogenesis in patients with peripheral artery disease to treatment of terminal liver failure, to treatment of heart disease. Unfortunately the use of...

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Cloning pigs using non-quiescent differentiated donor cells or nuclei

Patent Number: 7,291,764
Cloning and genetic manipulation of pigs is desirable not only for research uses but also for potential pharmaceuticals (ie generation of proteins in transgenic pig seminal fluid) as well as xenotransplantation of genetically modified pig organs into humans. Unfortunately cloning of pigs is more difficult than cloning of other species. In this patent methods of cloning pigs are provided...

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