Patents
Methods of using deacetylase inhibitors to promote cell differentiation and regeneration
Patent Number: 7,229,963The use of histone deacetylase inhibitors for inducing new gene expression of genes that are developmentally silenced is a very exciting method of "reactivating" stem cells. For example, the histone deacetylase inhibitor valproic acid is a clinically used agent that stimulates stem cell expansion. The current patent teaches ways...
Inventors: Sartorelli; Vittorio (Bethesda, MD), Puri; Pier Lorenzo (San Diego, CA)
Assignee: United States of America as represented by the Secretary of the Department of of Health Services, National Institutes of Health (Washington, DC)
Date of First Priority Issue: Thursday October 18th, 2001
Use of VEGF and homologues to treat neuron disorders
Patent Number: 7,226,908ALS is a neurodegenerative motor disease for which no curative therapies exist. Additionally, little is known as to what even causes this condition. Although in familial ALS (accounts for 10% of cases) about 20% of patients have a mutation in the enzyme superoxide dismutase, the meaning of this is relatively unknown. The current...
Inventors: Carmeliet; Peter (Landen, BE), Collen; Dee (Winksele, BE), Oosthuyse; Bert (Horml, BE)
Assignee: Vlaams Interuniversitair Instituut Voor Biotechnologie VZW (Ghent, BE)
Date of First Priority Issue: Thursday April 12th, 2001
Cell surface expressed marker of pluripotency
Patent Number: 7,226,994This patent covers the composition of matter for two markers that are widely used for detecting germ cells. The markers being Fragilis and Stella. These are found also in embryonic stem cells and primordial germ cells. The patent is useful for development of laboratory reagents, as well as clinically developing methods of isolating specific cell populations.
Inventors: Saitou; Mitinori (Cambridge, GB), Surani; Azim (Cambridge, GB)
Assignee: Cambridge University Technical Services Limited (GB)
Date of First Priority Issue: Thursday January 18th, 2001
Use of vascular endothelial growth factor to treat photoreceptor cells
Patent Number: 7,223,724Macular degeneration and various other types of ocular pathology are usually associated with uncontrolled proliferation of blood vessels near the retina. The covering of nerves by new blood vessels usually causes dysfunction of the nerves and in some cases blindness. It is known that the compound VEGF is associated with pathological angiogenesis, and accordingly, the prior art would teach away...
Inventors: Alderson; Ralph (Gaithersburg, MD), Melder; Robert (Boyds, MD), Roschke; Viktor (Rockville, MD), Ruben; Steven M. (Olney, MD), Rosen; Craig A. (Laytonsville, MD)
Assignee: Human Genome Sciences, Inc. (Rockville, MD)
Date of First Priority Issue: Monday February 8th, 1999
Inhibitors of proteasomal activity for stimulating hair growth
Patent Number: 7,223,554This patent covers the composition of matter for several inhibitors of proteasomal activity including inhibitors of the chymotrypsin-like activity, and NF-KB inhibitors that stimulate hair growth. The invention has demonstrated efficacy in several animal models and is currently being developed by the San Francisco company Neosil. One wonders whether inhibition of inflammation-associated...
Inventors: Garrett; I. Ross (San Antonio, TX), Rossini; Jorge Gianny (San Antonio, TX), Gutierrez; Gloria (San Antonio, TX)
Assignee: Osteoscreen, Ltd. (San Antonio, TX)
Date of First Priority Issue: Friday July 10th, 1998
Silica-calcium phosphate bioactive composite for improved synthetic graft resorbability and tissue regeneration
Patent Number: 7,223,414Delivery of growth factors along with stem cells is an important component of therapeutic regeneration. The current patent describes new resorbable silica-calcium phosphate bioactive composites that are useful for delayed release of various pharmaceuticals, including growth factors. Potential growth factors useful with this invention include administration of G-CSF with stem cells locally to...
Inventors: El-Ghannam; Ahmed (Lexington, KY)
Assignee: Unknown Assignee(s)
Date of First Priority Issue: Friday May 3rd, 2002
Compositions for identification and isolation of stem cells
Patent Number: 7,223,549This patent covers several antibodies that specifically bind ectodermally-derived stem cell but have weaker affinity for stem cells of mesodermal and endodermal origin. The antibodies seem to bind prostate and liver stem cells but not dermal stem cells. The antibodies are deposited with ATTC and are commercially available. Unfortunately, the ligand for the antibodies was not...
Inventors: Makarovskiy; Andrew N. (Mendon, MA)
Assignee: Marakovskiy Andrew N. (Mendon, MA)
Date of First Priority Issue: Monday May 22nd, 2000
Compositions for controlling hair growth
Patent Number: 7,223,562This patent covers a novel protein called follicular papilla-1 (FP-1), that is selectively expressed in follicular papilla but not in dermal fibroblasts. The patent covers the FP-1 composition of matter, as well as vectors expressing it, cells expressing it, and specific sequences. FP-1 is essential for hair growth has demonstrated by siRNA and antibody inhibition experiments. Additionally...
Inventors: Sun; Tung-Tien (Dobbs Ferry, NY), Cao; Qiong (Boston, MA)
Assignee: New York University (New York, NY)
Date of First Priority Issue: Monday March 31st, 2003
Method of making embryoid bodies from primate embryonic stem cells
Patent Number: 7,220,584This patent is an example of how a good patent strategy is executed. WARF has filed originally patents on the actual embryonic stem cells and their composition of matter. One of the best ways of differentiating cells from embryonic stem cells involves growing the embryonic stem cells as embryoid bodies, then subsequently digesting the embryoid body and collecting the cells you need. Optionally...
Inventors: Thomson; James A (Madison, WI), Marshall; Vivienne S. (Madison, WI), Swiergiel; Jennifer J. (Roscoe, IL)
Assignee: Wisconsin Alumni Research Foundation (Madison, WI)
Date of First Priority Issue: Monday February 21st, 2000
Stem cells that transform to beating cardiomyocytes
Patent Number: 7,220,582Inventors: Epstein; Neal D. (Chevy Chase, MD), Gopal; Thiru V. (North Potomac, MD), Winitsky; Steve O. (Bethesda, MD), Hassanzadeh; Shahin (Fairfax, VA)
Assignee: United States of America as represented by the Secretary of the Department of Health and Human Services (Washington, DC)
Date of First Priority Issue: Monday October 22nd, 2001