Patents
Compositions, systems and methods for treatment of defects in blood vessels
Patent Number: 7,201,918Vascular aneurysms are thinning of blood vessel walls, which is usually associated with vessel trauma, non-specific degeneration, atherosclerosis, or infection. The term "aneurysm" comes from the Latin "aneurysma" which means "dilation". Aneurysms are hazardous because of the potential to burst. They are usually prevelant in the aorta or cerebral arteries. The current patent provides methods...
Inventors: Cruise; Gregory M. (Rancho Santa Margarita, CA)
Assignee: Microvention, Inc. (Aliso Viejo, CA)
Date of First Priority Issue: Tuesday November 16th, 2004
Scaffolds for tissue engineered hair
Patent Number: 7,198,641This patent covers scaffolds that are useful for hair replacement. Essentially the patent has claims around a scaffold that is made of: - a bioabsorbable polymer - hair follicle progenitor cells The scaffold having the shape approximately to the shape of a hair follicle. The assignee company, Aderans Research Institute, Inc., is extensively involved in both making wigs, as well as...
Inventors: Barrows; Thomas H. (Austell, GA)
Assignee: Aderans Research Institute, Inc. (Beverly Hills, CA)
Date of First Priority Issue: Tuesday August 8th, 2000
Methods and devices for promoting endothelial morphogenesis
Patent Number: 7,198,798In the manufacture of various implantable medical devices it is important that the said device be able to endothelialize so that it integrates successfully with the host. When this doesn't happen various problems may arise such as restenosis, or inflammation at the site of device implantation. The current patent teaches that coating of devices with osteoprotegerin can be used to cause...
Inventors: Malyankar; Uriel M. (North Branford, CT), Scatena; Marta (Seattle, WA), Giachelli; Cecilia M. (Mill Creek, WA)
Assignee: University of Washington (Seattle, WA)
Date of First Priority Issue: Thursday May 10th, 2001
Myeloid precursor cell useful for gene therapy and for modulation of immune responses
Patent Number: 7,198,909Myeloid progenitor cells are known to be responsible for producing polymorphonuclear leukocytes as well as monocytes in the blood. Besides their well-known function in the classical hematopoietic system, myeloid progenitor cells ahve been reported by various groups to have immune modulatory function, specifically, the ability to inhibit immune responses through factors such as TGF, PGE, and other...
Inventors: Ron; Yacov (East Brunswick, NJ), Dougherty; Joseph P. (Hampton, NJ), Chen; Chiann-Chyi (East Brunswick, NJ)
Assignee: University of Medicine & Dentistry of New Jersey (New Brunswick, NJ)
Date of First Priority Issue: Saturday October 31st, 1998
Methods and compositions for obtaining mature dendritic cells
Patent Number: 7,198,948Dendritic cells are the most potent antigen presenting cell of the immune system. Essentially, they "tell" T cells what to attack and what not to attack. The first inventor of the current patent, Ralph Steinman is considered the discoverer of the dendritic cells. The patent covers a method of making dendritic cells from stem cells. According to the claims, the method involves culturing...
Inventors: Steinman; Ralph M. (Westport, CT), Bhardwaj; Nina (Montclair, NJ), Schuler; Gerold (Spardorf, DE)
Assignee: The Rockefeller University (New York, NY); Argos Therapeutics, Inc. (Durham, NC)
Date of First Priority Issue: Wednesday February 12th, 1992
Use of treosulfan for patient conditioning before bone marrow or blood stem cell transplantation
Patent Number: 7,199,162During bone marrow or peripheral blood stem cell transplant, it is typical to perform preconditioning of the recipient. This is done in order to wipe out host derived hematopoiesis, and to "make room" for the donor stem cells. Additionally, in conditions of hematological neoplasia, recipient conditioning is performed with the idea of eradicating cancer cells. Numerous protocols and procedures...
Inventors: Baumgart; Joachim (Appen, DE)
Assignee: Medac Gesellschaft fur Klinische Spezialpraparate mbH (Hamburg, DE)
Date of First Priority Issue: Friday November 5th, 1999
Mammalian cells that have increased proliferative capacity
Patent Number: 7,195,911This patent covers the expansion of telomeres in a wide variety of human cells using the telomerase reverse transcriptase. This patent belongs to a family of earlier Geron patents covering the overcoming of telomere shortening through induction of "telomerase" activity into cells. The IP field of telomerase is pretty crowded and this patent has to be read carefully by those interested in...
Inventors: Cech; Thomas R. (Potomac, MD), Lingner; Joachim (Epalinges, CH), Nakamura; Toru (San Diego, CA), Chapman; Karen B. (Southborough, MA), Morin; Gregg B. (Oakville, CA), Harley; Calvin B. (Palo Alto, CA), Andrews; William H. (Reno, NV)
Assignee: Geron Corporation (Menlo Park, CA)
Date of First Priority Issue: Tuesday October 1st, 1996
Protein-induced morphogenesis of kidney tissue
Patent Number: 7,196,056This patent has three main areas covered in its claims: 1. Induction of new kidney tissue growth. 2. Induction of kidney morphogenesis. 3. Repair of kidney tissue. These are performed by administration of appropriate concentrations of the following proteins: OP-1, OP-2, BMP-2, BMP-4, BMP-5, BMP-6, Vg1, Vgr-1, DPP, 60A, or GDF-1. This patent may be very important since numerous...
Inventors: Cohen; Charles M. (Weston, MA), Sampath; Kuber T. (Hollison, MA), Pang; Roy H. L. (Etna, NH), Oppermann; Hermann (Medway, MA), Rueger; David C. (Hopkington, MA)
Assignee: Curis, Inc. (Cambridge, MA)
Date of First Priority Issue: Monday March 10th, 2003
Method to enhance hematopoiesis
Patent Number: 7,196,060This patent teaches the use of a composition of matter called T-4 immune stimulating factor (TISF). This peptide was patented previously as a 50 kDa molecule in US patent # 5,616,554 as being useful for stimulation of CD4 T cell responses. The composition is derived from thymic cell lines and appears to be primarily immunostimulatory. In the current patent the use of TISF is claimed for...
Inventors: Beardsley; Terry Raymond (Escondido, CA), Maida, III; Anthony E. (Danville, CA)
Assignee: S-Cell Biosciences, Inc. (Murrieta, CA)
Date of First Priority Issue: Wednesday September 10th, 2003
Implantable biodegradable devices for musculoskeletal repair or regeneration
Patent Number: 7,192,604The current patent covers methods of producing biodegradable scaffolds for implantation of stem cells, committed progenitors, or differentiated cells into a host primarily for the purposes of healing or regenerating musculoskeletal tissue. Covered is an implantable device made of fibers with varying degrees of biodegradability designed so that scaffold degradation is coordinated with...
Inventors: Brown; Kelly R. (Hillsborough, NJ), Chun; Iksoo (Flemington, NJ), Hammer; Joseph J. (Bridgewater, NJ), Janas; Victor F. (Monroe Township, NJ), Mandanas; Jennifer (Painted Post, NY), Melican; Mora C (Bridgewater, NJ), Rezania; Alireza (Hillsborough, NJ), Z
Assignee: Ethicon, Inc. (Somerville, NJ)
Date of First Priority Issue: Friday December 22nd, 2000