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Bone Marrow Stem Cells for Renal Failure

Monday December 22nd, 2008 @ 18:13:58 EST

From Category: Use

São Paulo, Brazil -

Bone marrow is classically known to be the site of hematopoiesis, thus "bone marrow transplant" has been successfully used for decades as a means of treating various hematological malignancies in which the recipient hematopoietic compartment is replaced by donor-derived stem cells.  More recent investigations have demonstrated that several progenitor cells exist within bone marrow that are capable of differentiating into other tissues, for example cardiac tissue.  In fact, clinical trials have been conducted demonstrating beneficial effects of bone marrow infusion in cardiac patients.  It is believed that injured tissue, whether neural tissue after a stroke, or injured cardiac tissue, has the ability to selectively attract bone marrow stem cells, perhaps to induce regeneration.  While numerous studies have demonstrated bone marrow having therapeutic effect in conditions ranging from liver failure, to peripheral artery disease, the possibility of using bone marrow stem cells in kidney failure has been relatively understudied.

A recent paper (Alexandre et al. Lineage-Negative Bone Marrow Cells Protect against Chronic Renal Failure. Stem Cells 2008 Dec 18) addressed this question. 

Researchers used a rat model of chronic renal failure in which one kidney is excised so as to increase the load of the remaining kidney, thus causing a chronic deterioration that resembles the clinical situation of renal failure. 

The rats were divided into 4 groups. 

Group 1 were sham operated and both kidneys left in place. 

Group 2 had a kidney removed but were not administered cells. 

Group 3 were administered 2 million lineage negative bone marrow cells on day 15 after one of the kidneys was removed. 

Group 4 were administered 2 million lineage negative bone marrow cells on days 15, 30, and 45 after one of the kidneys was removed.

They found: 

- Expression of inflammatory cytokines was reduced on day 16 in the kidneys of rats recieving stem cells as compared to rats that were nephrectomized but did not recieve cells. 

- On day 60 rats recieving stem cells had decreased proteinuria, glomerulosclerosis, anemia, renal infiltration of immune cells and protein expression of monocyte chemoattractant protein-1, as well as decreased interstitial area.

-  Injured rats had higher numbers of proliferating cells in the kidney, whereas rats recieving stem cells had less. 

- Protein expression of the cyclin-dependent kinase inhibitor p21 and of vascular endothelial growth factor increased after nephrectomy and decreased after Lin(-) cell treatment.

- On day 120, renal function (inulin clearance) was improved in the rats which were administered bone marrow cells compared to controls.

This study supports the possibility of using bone marrow cells for various aspects of kidney failure.  Other studies have demontrated that administered stem cells promote kidney repair by secretion of IGF-1, it would be interesting to see if the lineage negative cells used in this study make more of this cytokine.


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6 Comments | Add Comment

jonnyboy said...

Created 2008-12-24 14:03:35 EST

Bone marrow stem cells are currently used for kidney failure in the US as part of a clinical trial in Utah by the company Allocure.

If you can not get accepted into that clinical trial there are other places that offer this as a fee for service such as www.cellmedicine.com which has sponsored some interesting videos on youtube about stem cells.

For information about how stem cells may be useful to treat kidney failure you may search the website www.pubmed.com which as every single scientific paper published since the late 1950s in the form of abstracts.  For searching clinical trials information the US government has put a central website at www.clinicaltrials.gov that lists every ongoing clinical trial.

Hope this helps !!!

 

Jonathan 

 

 

- 1 -

sohail said...

Created 2008-12-31 03:00:57 EST

 

 

Hi Jonathan,

 

Thanks a lot for the information will definetely check it out .

 

sohail

- 2 -

Edmond (Toronto) said...

Created 2009-07-01 01:20:03 EST

Hello

Is there any progress in stem cell research for chronic kidney failure??  If so, are there any clinical trials or studies going on at the present time??

Edmond Jando
- 3 -

Thomas said...

Created 2009-07-01 15:04:16 EST

Allocure out of Utah were doing some trials in kidney failure. 

Cellmedicine.com also are doing some work in this space

Hope it helps

Tom

 

- 4 -

stemcuredkidney said...

Created 2009-07-29 04:09:03 EST

Hi

 

I took cord blood stem cells and my kidney improved more then 20%. Shall be taking more, for sure, it works.

I can with my experience easily recommend for all others facing kidney problems,

 

take care

- 5 -

Sarif () said...

Created 2010-03-11 11:17:07 EST
i got kidney transplantation on last decembor. is any treatmeant of stem cell present to improve my own damage kidneys or to keep well transplanted kidney better rather than anti-rejection medicine? 
- 6 -

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