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Dear manoj kumar valluru,

An interesting paper of relevance to our field was published last week describing neural in vivo differentiation of tooth derived stem cells, and perhaps more interesting, activation and recruitment of endogenous neural progenitors. This is the second paper demonstrating in vivo activity of this type of cell, a while ago we discussed the paper demonstrating similar stem cells possessing cardiac regenerative activity.

Also interesting was a patent (#7,408,095) issued to the company Phylonix Pharmaceuticals covering the use of pre-immune zebrafish as an alternative immune deficient host for studying human cells, particularly cancer. Looks like the NOD-SCID mice will be out of a job !! (joke).

Another patent (#7,408,039) was issued covering the use of costimulatory blockade (CD28-CD80/CD86) or (CD40L-CD40) together with antibodies to CD2 as a method of blocking graft versus host disease after cytoreductive therapy.

 


Methods for introducing heterologous cells into fish to determine if the heterologous cells contain cancer cells or a pathogen
 
 
Patent Number: 7,408,095

In general it is quickly forgotten that the biggest contribution of embryonic stem cell technology to medicine has not been in the area of actually generating therapeutics, but in development of model systems for studying diseases. It was only through the generation of knockout and transgenic animals that we as biologists were able to start...[Read More]

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  Tooth in the Brain: Tooth Mesenchymal Stem Cells Made into Neurons

Sunday August 10th, 2008 @ 15:18:00 EST

Kaohsiung, Taiwan -

The ability of mesenchymal stem cells to differentiate into neurons and neuron-like cells has been documented.  For example, mesenchymal stem cells have been demonstrated to be beneficial in case reports of multiple sclerosis, as well as in early clinical...[Read More]

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