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Hello manoj kumar valluru,

Last week a paper was published describing that treated with the proteosome inhibitor Velcade could actually sensitize quiescent CML progenitors to killing by natural killer cells.  This is important since CML is one of the situations where immunological control of cancer has been well documented.

Two patents in the area of stem cells were issued last week.  # 7,435,718 discloses compositions of matter for antagonizing CXCR4 and # 7,435,592 covers T cells activated with anti-CD3 and anti-CD28 !  No joke !  this patent could be very useful given that anti-CD3 and anti-CD28 are the main ways of activating human T cells.

Compositions for allogeneic cell therapy     Patent Number: 7,435,592 Assignee | Inventor This patent covers a composition of activated T cells, either autologous or allogeneic.  It is very interesting since the way the claims issued, it covers pretty much any T cell that has been activated by ligation of CD3 and CD28 (the most common way of activating T cell cells).  The first independent claim covers a...[Read More] Ask a question OR leave your comments.

Sensitizing CML Precursors to GVL Sunday October 19th, 2008 @ 12:42:24 EST Bethesda, Maryland - Chronic myeloid leukemia (CML) is a cancer of the myeloid committed stem cell, which is caused primarily by the oncogenic chimeric protein BCR-ABL.  Immune responses are known to control progression of CML.  For example, patients with CML taking interferon that have higher NK cell...[Read More] Ask a question OR leave your comments. Read more StemCellPatents.com News

RMSC 2008 World Congress (2-4 December 2008)
The 3rd Annual Stem Cells World Congress (20-22 January 2009)
The Stem Cell Meeting (March 2009)

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