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Hello manoj kumar valluru,

Last week a paper was published describing pro-angiogenic effects of caloric restriction.  The effects were mediated by adiponectin since mice lacking adiponectin did not have an enhanced angiogenic response.  Given the correlation between caloric restriction and longevity, as well as the possible relationship between stem cell number and longevity, it would be interesting to see if their is a relationship between caloric restriction and stem cell activity.

Two patents were issued last week of interest to our field.  The first, #7,449,186, teaches how to mobilize CD34 cells by administration of antibodies to VCAM-1, which is found on stromal cells and binds VLA-4 on CD34 hematopoietic stem cells. 

The other patent, #7,449,333, provides a composition that can be sprayed onto wounds for acceleration of healing/reduction in fibrosis.  This composition is made of allogeneic fibroblasts, extracellular matrix components, and thrombin.

Methods of blocking the interaction between stromal cells and hemopoietic cells with anti-VCAM-1 antibodies     Patent Number: 7,449,186 Assignee | Inventor Mobilization is currently performed using agents such as G-CSF clinically, experimentally agents such as parathyroid hormone are being investigated.  The current patent teaches a new way to mobilize through blocking the interaction between hematopoietic stem cells and their...[Read More] Ask a question OR leave your comments.

Caloric Restriction Stimulates Angiogenesis Through Adiponectin Sunday November 16th, 2008 @ 12:57:10 EST Nagoya, Japan - Caloric restriction is by far the most documented method of extending lifespan.  People have filed patents on methods of identifying compounds that induce biological effects similar to caloric restriction.  There are several theories as to how caloric restriction mediates its...[Read More] Ask a question OR leave your comments. Read more StemCellPatents.com News

RMSC 2008 World Congress (2-4 December 2008)
The 3rd Annual Stem Cells World Congress (20-22 January 2009)
The Stem Cell Meeting (March 2009)

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