News Posts
G-CSF Stimulates Liver Repair
Rome, Italy - G-CSF is clinically used to stimulate neutrophil production in patients who are neutropenic as a result of cancer therapy. Experimentally G-CSF is under investigation for mobilization of stem cells to help patients after cardiac infarct or stroke. In a recent study (Piscaglia et al. Granulocyte-colony stimulating factor promotes liver repair and induces oval cell migration and...Wednesday August 8th, 2007 @ 10:43:28 EST
Mesenchymal Stem Cells and IDO
Verona, Italy - Mesenchymal stem cells are currently in Phase III of clinical trials in the US and are available as a fee for service in places such as Cellmedicine for the treatment of autoimmune/inflammatory conditions. A fundamental question, however, is what are the mechanisms by which mesenchymal stem cells inhibit pathological...Tuesday August 7th, 2007 @ 10:54:17 EST
IL-6 Causes Mesenchymal Stem Cells to Inhibit Lymphocyte Apoptosis
Piscataway, NJ Mesenchymal stem cells are a very strange type of cell. On the one hand they are known to suppress pathological activities of the immune system, and on the other hand they promote survival of T cells. In a recent study (Xu et al. The role of IL-6 in...Tuesday August 7th, 2007 @ 10:44:50 EST
CD9 a Marker of Adipose Stem Cell Activity
Pusan, South Korea - As stem cell therapeutics start entering the clinic it is going to be important to identify markers that can be used to quantify ability of the stem cells to perform various regenerative tasks. Such markers will be used for quality control and/or release testing of stem cell batches. A recent paper (Kim et al. Role of CD9 in proliferation and proangiogenic action of...Monday August 6th, 2007 @ 02:54:33 EST
From Sperm to Heart...well kind of...
Göttingen, Germany - Pluripotent stem cells derived from primordial germ cells have been previously described. What is more exciting is the possibility of using adult testicular cells as a source of pluripotent stem cells. This was actually published in Nature last year (Guan et al. Pluripotency of spermatogonial stem...Sunday August 5th, 2007 @ 21:32:42 EST
HLA-G Helps Lung Cancer Escape Immune System
Sichuan, China - We have previously discussed that HLA-G expression is an important mechanism by which mesenchymal stem cells suppress the immune system. In a recent paper (Yie et al. Expression of human leucocyte antigen G (HLA-G) is associated with prognosis in non-small cell lung cancer. Lung Cancer. 2007 Jul 27) the importance...Sunday August 5th, 2007 @ 20:25:10 EST
Mesenchymal Stem Cells Use HLA-G to Suppress T Cells
Cedex, France - The fact that mesenchymal stem cells are immune suppressive is established. This is one of the reasons why companies such as Osiris are trying to get them approved as an "off the shelf" product that does not require matching. Several mechanisms are known by which mesenchymal stem cells suppress the immune responseSunday August 5th, 2007 @ 18:38:12 ESTBlood to Muscle: Hematopoietic transdifferentiation to muscle
Providence, RI - Numerous scientists, such as Irv Weissman, continually make the point that a hematopoietic stem cell will only differentiate into a cell of the hematopoietic lineage. Such statements appear, at face value, to contradict the numerous clinical trials ongoing using bone marrow stem cells for the treatment of conditions ranging from heart failure, to liver failure, to peripheral...Sunday August 5th, 2007 @ 18:05:05 EST
Hyaluronic Acid Mediated Mesenchymal Stem Cell Migration
Much is known about CD34+ stem cell migration to areas of hypoxia due to secretion of SDF-1 (CXCL12) by the hypoxia tissue. Migration towards the CXCL12 gradient has been documented in diverse situations ranging from post-myocardial infarction CD34 mobilization to homing of hematopoietic stem cells to the bone marrow niche during transplantation. However signals that cause migration of...Saturday August 4th, 2007 @ 11:24:13 EST
MS Patient After Stem Cell Therapy
[Watch the Video] Numerous animal studies support the immunomodulatory activities of stem cells, especially mesenchymal stem cells. For example, expression of molecules such as IDO, IL-10 and TGF-beta by mesenchymal stem cells allows induction of tolerance, generation of Treg cells, as well as veto-like activity. Although there are clinical trials of mesenchymal stem cells in places...Friday August 3rd, 2007 @ 13:07:47 EST
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