News Posts
Wnt/beta catenin in regenerating liver ! stem cells everywhere !
Pittsburgh, PA - The Wnt pathway is involved in tissue morphogenesis and has been found activated in various stem cell types and cancers. In a recent paper (Apte et al. Wnt/beta-catenin signaling mediates oval cell response in rodents. Hepatology. 2007 Oct 10) it was demonstrated that this pathway is activated in adult liver stem cells (oval cells) after liver damage. To induce liver...Friday October 26th, 2007 @ 19:26:50 EST
Telomerase important in epidermal stem cells
Madrid, Spain - Shortening of telomeres is associated with cellular senescence. However, the shortening of telomeres is known to be associated not just with cell death but also dysfunction. For example, associations have been previously made between hypertension and telomere shortening (Fuster et al. Telomere dysfunction in hypertension. J Hypertens. 2007 Nov;25(11):2185-2192). In a recent...Thursday October 25th, 2007 @ 00:18:01 EST
Sheep with bad kidneys: intra-renal arterial mesenchymal stem cell administration
Paris, France - Bone marrow derived mesenchymal stem cells are most likely going to be the first stem cell type approved in the US for regenerative, non-hematopoietic purposes. Currently the company Osiris Therapeutics is leading the way by performing pivotal Phase III trials using these cells. The use of mesenchymal stem cells for treatment of ischemic kidney injury was recently reported...Tuesday October 23rd, 2007 @ 22:56:48 EST
Mesenchymal Stem Cell Therapy Kidney Failure: IGF-1
Bergamo, Italy - Although numerous studies, both preclinical and clinical have demonstrated the potency of adult stem cells for treatment of heart and liver degenerative conditions, relatively little work has been performed using stem cells for renal failure. In a recent paper (Imberti et al. Insulin-Like Growth Factor-1 Sustains Stem Cell Mediated Renal Repair. J Am Soc Nephrol. 2007 Oct...Tuesday October 23rd, 2007 @ 22:45:44 EST
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Talk with stem cell therapy doctor
[Watch the Video]Monday October 22nd, 2007 @ 00:49:12 EST
MyoD Deficiency Helps Muscle Stem Cells
Minneapolis, MN - MyoD is a basic helix-loop-helix myogenic transcription factor involved in differentiation of muscle cells. In a recent paper (Asakura et al. Increased survival of muscle stem cells lacking the MyoD gene after transplantation into regenerating skeletal muscle.Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16552-7) scientists wanted to determine whether muscle stem cells...Friday October 19th, 2007 @ 04:06:25 EST
Bone Marrow-Like Bioreactor
Detroit, Michigan - The ex vivo expansion of hematopoietic stem cells in large numbers would allow for numerous autologous transplant approaches to become a clinical reality. For example, one could hypothetically expand and keep frozen their own stem cells for when they need them later in life. Unfortunately, many attempts at expanding CD34 hematopoietic stem cells have failed to either...Friday October 19th, 2007 @ 03:56:03 EST
Porcine Adipose Stem Cells For Infarct Study
New Orleans, LA - The use of adult stem cells for heart failure has previously been reported. What is interesting is the possibility of using autologous adult adipose derived stem cells for this condition. The beauty of adipose derived stem cells is, of course, that they are available in autologous settings in large numbers...Wednesday October 17th, 2007 @ 10:15:41 EST
IVIG treats mouse model of multiple sclerosis by Treg upregulation
Paris, France - It has previously been reported that immunoglobulins play a fundamental role in stem cell mobilization. It is also known that intravenous immunoglobulin (IVIG) possesses numerous anti-inflammatory properties. In a recent paper (Ephrem et al. Expansion of CD4+CD25+ regulatory T cells by intravenous immunoglobulin: a...Tuesday October 16th, 2007 @ 14:51:27 EST
New T regulatory marker found: Folate Receptor 4
Kyoto, Japan - One of the exciting uses of stem cells is suppression of inflammatory reactions. In other words, various types of stem cells, such as mesenchymal stem cells, are known to possess membrane-bound molecules that inhibit T cell activation, or soluble products such as HLA-G5 which also inhibits T cell activation. The immune system can be regulated by stem cells through another means...Tuesday October 16th, 2007 @ 14:38:43 EST