News Posts
Stem Cell Cancer Therapy
Bratislava, Slovakia - Various types of stem cells are known to home specifically into neoplastically transformed tissue. In a recent paper (Kucerova et al. Adipose tissue-derived human mesenchymal stem cells mediated prodrug cancer gene therapy. Cancer Res. 2007 Jul 1;67(13):6304-13) this property was leveraged in order to provide...Thursday July 12th, 2007 @ 16:05:51 EST
Usefulness of Amniotic Fluid Stem Cells
Punjab, India - Readers of ours may remember the discussion we had on the Wake Forest finding regarding amniotic stem cells. In a recent paper (Rehni et al. Amniotic fluid derived stem cells ameliorate focal cerebral ischaemia-reperfusion injury induced behavioural deficits in mice. Behav Brain Res. 2007 May 26) the utility of these...Thursday July 12th, 2007 @ 15:58:17 EST
Telling Mesenchymal Stem Cells Where to Go
Birmingham, Alabama, USA - Stem cell migration is an important issue. In situations like bone marrow transplantation for hematpoietic reconstitution, the hematopoietic stem cells are "told" to home to the bone marrow of the recipient by virtue of molecules such as SDF-1 which are secreted by bone marrow stromal cells. The signals...Thursday July 12th, 2007 @ 15:49:31 EST
Why Sorted CXCR4+ and CXCR4- Stem Cells Have Similar Engraftment
[Watch the Video] This video reviews data that explains why CXCR4+ stem cells and CXCR4- stem cells home with similar efficiency to the bone marrow. The answer is that the CXCR4 antibody actually blocks signalling, and that CXCR4- cells actually contain intracellular stores of CXCR4 which can be upregulated by cytokines.Sunday July 8th, 2007 @ 14:43:34 EST
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Accelerating Mesenchymal Stem Cell Migration
Beijing, China - Mesenchymal stem cells are currently being explored by companies such as pluristem for the acceleration of bone marrow hematopoietic stem cell engraftment after transplantation. In a recent study (Shi et al. Regulation of CXCR4 expression in human mesenchymal stem cells by cytokine treatment: role in homing efficiency in NOD/SCID mice. Haematologica. 2007 Jul;92(7):897-904...Friday July 6th, 2007 @ 01:59:15 EST
Mesenchymal Stem Cells Do Not Activate Cytotoxic T Lymphocytes
Stockholm, Sweden - Mesenchymal stem cells are far advanced in clinical development with trials being conducted for conditions ranging from multiple sclerosis to Crohn's Disease. One attractive aspects of these cells is their relatively low immunogenicity, thus offering the possibility of performing transfer across allogeneic barriers...Thursday July 5th, 2007 @ 11:40:06 EST
Systemic Administration of Endogenous Stem Cell Activator
Frankfurt, Germany - Valproic acid is a histone deacetylase inhibitor which is clinically used for the treatment of bipolar disorders and epilepsy. Valproic acid has been demonstrated to increase proliferation and expansion of CD34 stem cells in vitro. Additionally, valproic...Wednesday July 4th, 2007 @ 01:06:19 EST
Bone Marrow Stem Cell Background
[Watch the Video] This is a general introductory video about stem cells derived from the bone marrow and therapeutic uses.Sunday July 1st, 2007 @ 16:19:18 EST
Bone Marrow Stem Cell Expansion for Bone Formation
Cleveland, Ohio – Numerous studies have shown therapeutic potential of bone marrow derived stem cells for accelerating healing of bone injuries. Unfortunately, to date, few in vitro bone marrow stem cell expansion systems exist that can produce scalable quantities of stem cells in a easy to use and widely applicable manner. Recently, a paper (Dennis et al. Clinical-scale Expansion Of a...Tuesday June 26th, 2007 @ 02:21:06 EST
CD133 is marker of liver stem cells
Los Angeles, CA - The liver is one of the most regenerative organs, with potential to reconstitute original mass even after 2/3 resection. It has been previously postulated that oval cells have stem cell-like ability and are involved in regeneration of liver after resection. In fact, it was even postulated that oval cells derived from the bone marrow (Oh et al. Bone marrow-derived hepatic...Monday June 25th, 2007 @ 01:18:10 EST