News Posts
Intestinal Stem Cells Expand After Iliocecal Resection
Houston, Texas - It is known that subsequent to various types of intestinal surgeries, the remaining tissue compensates by augmentation of the mucosal surface area. In a recent study (Dekaney et al. Expansion of intestinal stem cells associated with long-term adaptation following ileocecal resection in mice. Am J Physiol Gastrointest Liver Physiol. 2007 Sep 13;) it was found that one of the...Monday September 17th, 2007 @ 15:52:00 EST
Stem Cells Mobilized by Heart Attacks
[Watch the Video] This video discusses how heart attacks generate VEGF which mobilizes stem cells to leave the bone marrow and enter systemic circulation, presumably on the way to the heart. Interestingly, the paper reviewed in the video was published in 2001. Since then numerous other studies have demonstrated VEGF and other soluble mediators are involved in chemotaxis of cells from bone...Sunday September 16th, 2007 @ 02:04:54 EST
A New Stem Cell Type
[Watch the Video] This video describes the Nature Biotechnology paper in which amniotic fluid derived stem cells were described in some detail. Of particular interest in the video is the discussion that these cells, which are isolated based on positivity for c-kit actually express Oct-4, which is a marker of embryonic stem cells. The video was posted by the stem cell clinicViral killing of tumor stem cells
Helsinki, Finland It is to be expected that tumor cells possess altered biological characteristics in comparison to their non-malignant counterparts. One very interesting method of targeting tumors is through the use of viruses that have a specific tissue trophism towards neoplastically transformed tissue. For example, it is known that human reovirus can only grow in cells that have an...Thursday September 13th, 2007 @ 22:27:57 EST
Tumors Calling Stem Cells
Galway, Ireland - The possibility of stem cells inducing tumor cell differentiation and thus reducing pathological potential has been speculated by numerous scientists. However, few studies have actually demonstrated that intravenously administered stem cells actually home to the area of tumor localization. Recently it was published (Dwyer et al Monocyte chemotactic protein-1 secreted...Sunday September 9th, 2007 @ 13:50:28 EST
Stem Cell Therapy for Peripheral Artery Disease
[Watch the Video] This is a video describing the use of stem cells for treatment of peripheral artery disease. Numerous publications have supported the safety and efficacy of this approach which seems to not only directly cause angiogenesis but also mobilize host stem cells which apparently contribute to revascularizationFriday September 7th, 2007 @ 16:29:21 EST
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More Seaweed Mobilization
Calgary, Canada - The people behind the company StemTech (multilevel marketing of a product called StemEnhance which supposedly increases circulating stem cells by mobilization) have published a paper describing possible mechanism of action for their stem cell mobilizer (Jensen et al. Mobilization of human CD34CD133 and CD34CD133 stem cells in vivo by consumption of an extract from...Tuesday September 4th, 2007 @ 10:12:48 EST
Activators of Endogenous Stem Cells for Diabetes Therapy
[Watch the Video] Discussed is the use of gastrin and EGF to stimulate endogenous stem cells for regeneration of islets. The paper is striking since not only is diabetes stopped and active islet regeneration occurred...but suppressor cells seemed to be generated that actively blocked diabetogenic activity of splenocytes. The EGF+Gastrin company has passed Phase IIa clinical trials and...Sunday September 2nd, 2007 @ 14:22:16 EST
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Complement Needed for G-CSF Mobilization
[Watch the Video] The possibility of the immune system doing other things than killing pathogens has been suggested by people like Polly Matzinger for decades. In this paper the authors identified that the C5 component of complement is strictly needed for G-CSF induced mobilization.Saturday September 1st, 2007 @ 01:56:02 EST
Protective Astrocytes
Galveston, Texas - As various media are being developed for coaxing stem cells to enter various pathways of differentiation, limitations to media alone are becoming apparent. In a recent study (Jordan et al. Astrocytes enhance long-term survival of cholinergic neurons differentiated from human fetal neural stem cells. J Neurosci Res. 2007 Aug 29) it was demonstrated that fetally derived...Friday August 31st, 2007 @ 11:02:16 EST
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