Class: Use (276)
Medicinal preparation based on fetal cell suspension having immune substituting effect for patients with acquired immune deficiency syndrome (HIV infection)
Patent Number: 6184033This patent teaches the administration of fetal cells, including stem cells, for the treatment of HIV infection. Various stem cells are known to secrete anti-inflammatory compounds such as TGF-beta. One possible mechanism of action is that stem cells secrete these antiinflammatory compounds, which in turn inhibit NF-kappa B, which does not...
Methods of screening for a candidate compound able to bind to CD34.sup.+ cells
Patent Number: 5965457This patent covers methods of screening for identifying which compounds bind to purified CD34+ cells. Since CD34+ cells are stem cells of the hematopoietic lineage, by identifying agents that bind to them it is possible to generate novel ways of purifying and identifying them.
Method of treating heart failure using leukemia inhibitory factor antagonists optionally with endothelin antagonists
Patent Number: 5837241This patent covers antagonizing either or both the endothelin receptor and the LIF receptor. Methods of action by which this combination inhibits heart failure may have to do with modulation of stem cell function.
Use of leukemia inhibitory factor and endothelin antagonists
Patent Number: 6156733This patent teaches how to treat heart failure by administration of antagonists to endothelin and LIF.
Isolated stromal cells for treating diseases, disorders or conditions characterized by bone defects
Patent Number: 5716616This patent teaches that stromal cells may be used for the treatment of various bone disorders, as well as regeneration of bone. How are these stromal cells related to the mesenchymal stem cells that Osiris is using?
Methods of treating disorders of the eye
Patent Number: 6750196This patent teaches expansion of retinal cells, and stem cells thereof, through the administration of proteins called neuroregulins. The patent is useful for treatment of a variety of ocular degenerative diseases.
Mesenchymal stem cells for cartilage repair
Patent Number: 6214369This patent covers the use of mesenchymal stem cells for generation of bone and cartilage. It is interesting that Osiris has patents in this area as well.
Mesenchymal stem cells for cartilage repair
Patent Number: 5906934This patent covers the use of mesenchymal stem cells for generation of artificial bone and cartilage. It is interesting that this patent was issued in light of Osiris's domination of the field of mesenchymal stem cells. This patent should be read in light of the other mesenchymal stem cell patents.
Development and use of human pancreatic cell lines
Patent Number: 6110743This patent covers islet stem cells and cell lines that generate islet cells. This patent could be useful for the treatment of type 1 diabetes. In some cases, it may be beneficial to encapsulate the cell lines so as to avoid immune mediated rejection. Alternatively these cells would provide a great source of tissue for using the Edmonton Protocol.
Recombinant vectors for reconstitution of liver
Patent Number: 5980886This patent covers ways of transfecting liver cells in vivo through the induction of liver stem cell activation by first transfection with a gene such as tPA or uPA, and then once the cells are proliferating, transfection with another gene that is therapeutic.