Class: Use (276)
Allogeneic and xenogeneic transplantation
Patent Number: 6911220This patent is for a very interesting idea. The induction of tolerance by ablating recipient T cells and recipient thymus, introducting a donor fetal or neonatal thymus, and allowing recipient T cells to mature with the donor thymus. This is based on the whole concept of inducing negative selection so that the recipient T cells will not kill the donor graft...but instead recognize it as...
Hematopoietic stem cell specific gene expression
Patent Number: 5556954This patent covers the promoter for CD34. CD34 is a classical marker of stem cells, not only of the hematopoietic type but also of the hepatic type. CD34 is highly glycosylated and acts as an adhesion molecule. Mice that are knocked out for CD34 still have hematopoiesis, however the stem cells to not migrate...
Repopulation of testicular seminiferous tubules with foreign cells, corresponding resultant germ cells, and corresponding resultant animals and progeny
Patent Number: 6215039This patent teaches ways of repopulating the testicles with stem cells and/or other cells so that the resulting animal may have offspring that are genetically different.
Compositions and methods for producing and using homogenous neuronal cell transplants to treat neurodegenerative disorders and brain and spinal cord injuries
Patent Number: 6214334This patent covers a neuronal stem cell line that is useful for treatment of central and peripheral nervous system disorders.
High efficiency gene targeting in mouse embryonic stem cells
Patent Number: 6653113This patent teaches ways of generating knockout mice through targeting of the mouse embryonic stem cell with the various targeting constructs and approaches that are disclosed.
Remyelination of neurons using multipotent neural stem cell progeny
Patent Number: 7,166,277This patent is useful for the cell therapy of diseases associated with demyelination such as multiple sclerosis. The patent covers the use of neural stem cells expanded ex vivo for the purpose of remyelinating neurons in vitro and in vivo. Specifically the patent covers use of nestin positive progenitors purified from CNS tissue treated with various...
Neural transplantation using proliferated multipotent neural stem cells and their progeny
Patent Number: 6497872This patent covers the use of a multipotent neural stem cell for transplantation into patients suffering from various neurodegenerative disorders. Markers of the cells suitable for transplantation, as well as culture conditions, and genes which the stem cells can be transfected with are provided.
Use of multipotent neural stem cells and their progeny for the screening of drugs and other biological agents
Patent Number: 6294346Great advances in combinatorial chemistry and in silico design have fast outpaced the availability of biological systems that can be screened using high-throughput systems. In this patent various neural stem cells and their progeny are claimed for use as screening targets in drug discovery.
Method of reconstituting hematopoietic cells using monoclonal antibodies to the stem cell factor receptor
Patent Number: 5906938This patent provides antibodies that stimulate the receptor c-kit and allow for enhancement of hematopoiesis. This patent may be useful not only for stimulation of hematopoiesis, but for stimulating other tissue specific stem cells that also express c-kit...these include endogenous cardiac and other muscle stem cells.
Use of GM-CSF to promote accelerated wound healing
Patent Number: 6689351This patent teaches that the hematopoietic stem cell stimulatory cytokine GM-CSF, which is clinically used today, can also be used for acceleration of wound healing when applied topically. This brings the question of what other stem cell stimulatory cytokines may be used to stimulate regeneration or healing of other tissues? The sky is the limit !!