Class: Use (276)
Methods for enhancing angiogenesis with endothelial progenitor cells
Patent Number: 5980887This patent covers the use of various endothelial stem cells, and stem cells that resemble hematopoietic stem cells, for the stimulation of angiogenesis. Cell types covered include: CD34+, Tie+, or flk-1+. Methods of expanding the cells in vitro prior to implantation are also disclosed.
Treatment of inner ear hair cells
Patent Number: 6593290This patent teaches that IGF-1 and/or FGF-2 are useful for the stimulation of ear hair stem cell expansion. This invention may be used for preventing hearing loss. FGF2 is approved in Japan for certain indications, including some associated with the ear.
Methods and use of motoneuronotrophic factors
Patent Number: 6841531This is a composition of matter patent on some endogenous factors that stimulate repair and regeneration of motor neurons. The authors have demonstrated some significant biological activities of the "motoneuronotrophic" factors in nerve injury, including ability to accelerating healing after cutting of the sciatic nerve in rats.
Unactivated ungulate oocytes to produce a cloned ungulate by nuclear transfer
Patent Number: 7,321,076This patent is of the same family as the original patents on cloning by Dr Wilmut's group. Essentially the patent's overall main claim is represented in the first independent claim which states: Cloning an ungulate comprising: (i) fusing a diploid, ungulate differentiated cell with an unactivated, enucleated metaphase II-arrested oocyte of the same species to reconstruct an embryo; (ii...
Pharmaceuticals containing multipotential precursor cells from tissues containing sensory receptors
Patent Number: 6969608This patent covers the use of a type of stem cell composition derived from tissues having sensory receptors such as olfactor epithelium. The patent contains 1 independent claims. The first covers a composition of neural stem cells and a carrier, the neural stem cells being isolated from tissue containing sensory receptors, expressing nestin, proliferate in absence of EGF... This patent teaches the treatment of HIV by reconstituting the immuen system with cells that can not be infected since they lack the HIV receptor or co-receptor.
This patent is neat since theoretically it would not need immune suppression since the HIV will perform the task of selecting only for the cells that... This patent teaches how to induce allogeneic tolerance to transplanted grafts through making the recipient a chimera in terms of blood composition. In other words, donor hematopoietic stem cells are administered in order to make the recipient have both donor blood cells circulating, as well as some left over recipient cells.
This system has been shown effective in several animal... This patent covers the generation of an artificial skin that has a keratinocyte layer and a dermis-forming layer. The second layer can be generated by use of mesenchymal stem cells. This patent could be useful not only for covering of burn patients or sufferers of wounds that take a long time to heal, but it could also be useful for generation of in vitro systems for assessing ability of... This patent teaches ways of generating knockout mice through a new targeting vector. Alternatively, knockout human embryonic stem cells can be made by this approach for generation of new tissues.
Hematopoietic cell method for treatment of HIV infection
Patent Number: 6365404
Mixed chimerism and tolerance
Patent Number: 6877514
Methods for prevention and/or treatment of neutropenia
Patent Number: 5851534
Multilayer skin or dermal equivalent having a layer containing mesenchymal stem cells
Patent Number: 6497875
I-Sce I induced gene replacement and gene conversion in embryonic stem cells
Patent Number: 6566579