Class: Use (276)
Agents for preventing and treating thrombocytopenia
Patent Number: 6956022This patent teaches the use of an existing pharmaceutical, parathyroid hormone (or agonists of the parathyroid hormone receptor) for stimulation of platelet production. The patent has one issued claim which covers essentially what was just mentioned. This is an interesting patent because in a publication it states that "Between 1958 and the late 1970s it was learned that
Methods of preparing bone marrow stromal cells for use in gene therapy
Patent Number: 6991787This patent involves using gene-transfected bone marrow cells as a way of delivering the gene of interest to a tissue that needs it. For example, lets take stroke patients. Conceptually one could administer a therapeutic gene directly into the area of cell death, or in proximity to it, in order to prevent further cell death or to induce regeneration of neurons. This approach is complex since...
Neural transplantation using pluripotent neuroepithelial cells
Patent Number: 7048921This patent covers ways of treating neurological deficiencies or damage through transplantation of specific types of stem cells, or progenitor cells. Specifically, the patent has 3 independent claims. The first independent claim covers the intracerebrally transplantation of pluripotent, nestin-positive, neuroepithelial cells that have been conditionally immortalized through genetic...
Biological material containing bone marrow stem cells partially or completely differentiated into connective tissue cells and a hyaluronic acid ester matrix
Patent Number: 6596274This patent provides materials that are biologically compatible, combined with bone marrow stem cells and/or progeny, for regenerative uses.
Tissue-engineered bone repair using cultured periosteal cells
Patent Number: 5700289This patent teaches that in some situations, cells from the periosteum can be grown and used as a "stem cell like" population for the treatment of bone defects.
Materials and methods relating to the transfer of nucleic acid into quiescent cells
Patent Number: 6723561The early hematopoietic stem cells are usually non-proliferating, additionally, intermediately developed hematopoietic stem cells treated with stem cell inhibitors such as TGF-beta, also do not proliferate. This causes a problem for gene therapy since most gene therapy vectors require the cells to be proliferating for appropriate transfection. This patent teaches...
Methods and compositions to improve germ cell and embryo survival and function
Patent Number: 6140121This patent provides compounds that are capable of increasing the viability of germ cells and embryos both in vitro and in vivo.
Cloning ungulates from a quiescent donor cell
Patent Number: 7,232,938This is one of the original cloning patents from the inventor of Dolly the sheep :) It covers a method of cloning an ungulate comprising: (i) providing a quiescent ungulate cell as a diploid donor cell; (ii) fusing the diploid donor cell to an enucleated oocyte recipient of the same species as the donor cell, thereby obtaining a reconstituted cell; (iii) activating the oocyte...
Serial nuclear transfer of ungulate embryos
Patent Number: 7,321,075This patent covers a method of cloning in which the nucleus is transferred across generations. The first claim exemplifies the basis of what is covered, which is essentially "serial nuclear transfer" by a) taking a transgenic nucleus b) culturing the nucleus in an embryo c) splitting the embryoin into cells d) taking the nucleus from the cells and using it to insert into oocytes in...
Ungulates produced by nuclear transfer of G1 cells
Patent Number: 7,304,204This patent is one of Ian Wilmut's family of patents covering various aspects of the cloning procedure. In this particular patent cloning of an ungulate (e.g. pigs, horses, sheep, or goats) is covered through the use of nuclear transfer in which the donor nucleus is in the G1 phase of the cell cycle and the recipient oocyte is blocked in the metaphase II phase and enucleated.