Class: Use (276)
Myoblast therapy for cosmetic treatment
Patent Number: 7,341,719One of the regenerative cells of the muscle is the myoblast. These cells essentially act as muscle stem cells, having the ability to multiply after injury and form muscle by fusing with other myoblasts. Myoblasts are very practical for cell therapy since they may be easily extracted from autologous sources and grown in vitro. Additionally, there is some evidence that myoblasts, upon fusing...
Leukemia inhibitory factor from mammalian species and use thereof to enhance implantation and development of embryos
Patent Number: 5962321This patent teaches the use of the cytokine LIF for increasing the rate of implantation of embryos. This patent is useful for generation of knockout and transgenic mice.
Cell compositions for use in transplantation
Patent Number: 6068836This patent teaches how to transfect quiescent hematopoietic stem cells. Transfection of these primitive stem cells should be useful for a variety of gene therapy applications including treatment of several metabolic diseases such as Krabbe Disease.
Methods for treatment of pulmonary disease using GM-CSF
Patent Number: 6019965This patent teaches that the administration of the clinically-used cytokine GM-CSF is useful for the treatment of alveolar proteinosis. This patent would be great to use in combination with systemically administered stem cell therapy since most stem cells given intravenously end up in either the lung or the liver.
Bone precursor cells: compositions and methods
Patent Number: 5972703This patent teaches the isolation, expansion, and use of bone stem cells that are separated from bone marrow cells.
Gene therapy by administration of genetically engineered CD34.sup.+ cells obtained from cord blood
Patent Number: 6984379This patent covers the use of autologous cord blood CD34 cells transfected with the adenosine deaminase gene for the treatment of severe combined immunodeficiency (SCID). The patent has 3 independent claims, the first covering a method of expressing a therapeutic agent in a human (but specifically restricted to adenosine deaminase), the second a method of treating a...
Methods of stimulating angiogenesis in a patient by administering vascular endothelial growth factor 2
Patent Number: 7,186,688VEGF (vascular endothelial growth factor) is a potent endothelial cell mitogen that has previously been used in clinical trials for therapeutic angiogenesis. The current patent covers the use of specific fragments of VEGF for the stimulation of angiogenesis and the treatment of various conditions. Specific conditions for treatment include...
Materials and methods for management of hyperacute rejection in human xenotransplantation
Patent Number: 7,201,899Xenogeneic transplants from lower animals to humans are prevented in part by the hyper-rejection phenomena which ensues as a result of preformed antibodies against alpha-gal epitopes. Alpha-gal epiptopes are generated as a result of activity of the enzyme alpha.-1,3 galactosyltransferase. This patent covers cells, including ES cells, for generation of knockout pigs or organs which lack...
Pharmaceutical preparation based on fetal suspension and methods of treating acquired immune deficiency syndrome (HIV injection)
Patent Number: 5811089This patent covers the injection of fetal hematopoietic organs, and extracts thereof, for the treatment of HIV.
Myocardial grafts and cellular compositions
Patent Number: RE37,978This patent is useful for anyone who is performing embryonic stem cell differentiation applications and desires a method of purifying unique differentiated cells from the embryonic stem cell. Since embryonic stem cells spontaneously differentiate into various lineages depending on culture conditions, this patent provides means of "fishing out" cells based on activation of cell-specific...