Class: Expansion (424)
Stem cell inhibiting proteins
Patent Number: 5856301This patent covers the inhibition of stem cell proliferation through administration of MIP-1 alpha or LD78. It is interesting to ask whether these compounds also inhibit proliferation of leukemic stem cells. If they do not, the use of these compounds may selectively protect healthy hematopoietic stem cells but allow killing of the leukemic...
Methods for suppressing myeloid cells with chemokines
Patent Number: 6165459This patent teaches that administration of various chemokines, such as, for example MIP-1 alpha or IL-8, inhibits the production of myeloid stem cell derived cells such as granulocytes or monocytes.
Compositions of myeloid-cell-suppressive chemokines
Patent Number: 6143289Disclosed are methods of inhibiting production of myeloid lineage hematologic cells through the administration of various members of the chemokine family. Chemokines useful for inhibiting myeloid cell production include MIP1 alpha, and beta, IL-8, PF4, and MCAF.
IL-3 variant hematopoiesis fusion protein
Patent Number: 7091319This patent covers fusion proteins of IL-3, that are useful for the growth, expansion, and in vivo expansion of stem cells. Although IL-3 and its fused partners are primarily important for hematopoietic stem cell expansion, the fusion proteins may have numerous other uses, including expanding hematopoietic-like stem cells that may be used for regenerative applications. The patent has numerous...
Methods of ex-vivo expansion of hematopoietic cells using interleukin-3 (IL-3) multiple mutation polypeptides
Patent Number: 6440407This patent covers IL-3 and various forms of it for the expansion of hematopoietic stem cells outside of the body.
Methods of ex-vivo expansion of hematopoietic cells using multivariant IL-3 hematopoiesis chimera proteins
Patent Number: 6436387This patent covers chimeric proteins that are based on the cytokine interleukin-3. The specific use of these proteins for expanding stem cells of the hematopoeitic lineage outside the body are disclosed.
Methods of ex-vivo expansion of hematopoietic cells using interleukin-3 mutant polypeptides with other hematopoietic growth factors
Patent Number: 6413509This patent provides variants of interleukin 3 that are useful for the expansion of stem cells in general, and specifically hematopoietic stem cells. These stem cells may be expanded for a variety of uses including for autologous stem cell transplantation. When methods of inducing hematopoietic stem cell differentiation into other types of tissues are figured out, this patent will be...
Methods of using multivariant IL-3 hematopoiesis fusion protein
Patent Number: 6361977IL-3 is an important cytokine not only for hematopoietic stem cell proliferation and differentiation, but also for other immune cells and non-hematopoietic stem cells. This patent provides various compositions of matter relating to proteins that stimulate the IL-3 receptor.
Co-administration of interleukin-3 mutant polypeptides with CSF'S for multi-lineage hematopoietic cell production
Patent Number: 6361976This patent teaches the use of various proteins that activate the IL-3 receptor in combination with other hematopoietic growth factors for the stimulation of hematopoietic stem cell proliferation.
Co-administration of interleukin-3 mutant polypeptides with CSF's for multi-lineage hematopoietic cell production
Patent Number: 6093395This patent teaches various forms of IL-3 together with various stem cell stimulatory factors for the expansion of hematopoietic stem cells.