Class: Expansion (424)

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Treatment methods using homeopathic preparations of growth factors

Patent Number: 6485480

The process of ultradiluting a compound in order to magically "potentiate" various effects has been used for hundreds of years in the area of homeopathic medicine. Homeopathy is based on the principle of "like cures like", in the sense that if you are allergic to a specific compound, the ultradilution of that compound, prepared through a magical shaking during the dilution process, will result...

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Homeopathic dilutions of growth factors

Patent Number: 5629286

This is a patent on using the technique of homeopathy (ultra-dilution with potentiation) in order to generate stem cell stimulants and other growth factors. This patent is very exciting...if the data is reproducible it could revolutionize medicine.

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Methods for treating disorders by administering radio frequency signals corresponding to growth factors

Patent Number: 5626617

This patent teaches that stem cells can be expanded by applying radiofrequencies that correspond with growth factors. This is a very interesting approach since conceptually the radiofrequencies can be used as pharmaceuticals. This patent definately deserves further investigation.

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Differential expansion of fetal stem cells in maternal circulation for use in prenatal genetic analysis

Patent Number: 5580724

This patent teaches how to expand fetal cells found in the maternal blood so as to be able to perform genetic tests without the need for amniocentesis. Since some have reported fetal stem cells in maternal circulation, it may be possible to use the technique in this patent, or a variation thereof, for obtaining fetal stem cells at various stages of development.

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Methods for stimulating granulocyte/macrophage lineage using thrombopoietin

Patent Number: 5989537

As the name "thrombopoietin" implies, this cytokine is conventionally viewed as a stimulator of platelet production. In this patent the use of thrombopoietin for stimulation of the granulocytic/monocytic lineage is claimed. Currently numerous companies are developing agonists and agonistic antibodies of the thrombopoietin receptor.

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Method of stimulating hematopoiesis with hemoglobin

Patent Number: 5631219

This patent teaches that hemoglobin itself may have hematopoietic stem cell stimulatory properties. The ability of hemoglobin chains has been described by others for stimulation of stem cell proliferation, and in some cases inhibition. This patent covers purified hemoglobin, mutant hemoglobin, and various recombinant hemoglobins. In Feb 25, 1998, Somatogen was bought by Baxter for...

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Methods of using flt3-ligand in hematopoietic cell transplantation

Patent Number: 7,294,331

Flt3 ligand is a potent stimulator of hematopoietic stem cell proliferation. This cytokine has other effects as well, such as increasing the number of dendritic cells, particularly of the lyphoid phenotype. The current patent covers the use of Flt3 ligand in transplantation of hematopoietic stem cells. Particularly the administration of Flt3 ligand before introduction of hematopoietic...

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Medium containing flt3 ligand for culturing hematophoietic cells

Patent Number: 6919206

This patent covers the use of flt-3 ligand for expanding hematopoietic stem cells in vitro. The importance of expansion techniques is seen in that numerous groups have tried and are still trying to identify ways of generating large populations of autologous stem cells. The patent is pretty straight-forward and has 2 independent claims: A hematopoietic cell expansion...

Assignee: Immunex Corporation (Thousand Oaks, CA)

Date of First Priority Issue: Monday March 7th, 1994

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Methods for stimulating erythropoiesis using hematopoietic proteins

Patent Number: 6316254

This patent covers the use of TPO (thrombopoietin) for the stimulation of hematopoietic stem cells to differentiate into red blood cells. Classically, as the name implies, TPO is considered a growth factor that induces differentiation of hematopoietic stem cells into the megakaryocytic lineage (ie to make platelets).

Inventor: Kaushansky, Kenneth (Woodinville, WA)

Assignee: University of Washington (Seattle, WA

Date of First Priority Issue: Monday February 14th, 1994

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Human haemopoietic maturation factor polypeptides

Patent Number: 5986069

This patent covers peptides that inhibit HELA cell proliferation, but are stimulatory to T cells and hematopoietic stem cells.

Inventors: Kirkness, Ewen F. (Olney, MD); Adams, Mark D. (North Potomac, MD); Olsen, Henrick S. (Gaithersburg, MD); Rosen, Craig A. (Laytonsville, MD)

Assignee: Human Genome Sciences, Inc. (Rockville, MD)

Date of First Priority Issue: Tuesday January 25th, 1994

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