Class: Expansion (424)
In vitro propagation of embryonic stem cells
Patent Number: 7,186,883Murine embryonic stem cell lines have revolutionized molecular biology by allowing the generation of transgenic and knockout mice. This technology allows for in vivo understanding of specific genes through either inducing over expression or complete silencing in a live animal. This patent covers methods of generating murine embryonic stem cells.
Methods and device for culturing human hematopoietic cells and their precursors
Patent Number: 5635387This patent provide conditions and systems for the ex vivo expansion of hematopoietic stem cells. Specific cell concentrations, growth factors, and vessels are provided. This patent is useful for expansion of cells either in the autologous situation, or in situations where an allogeneic source is not sufficient, such as in cord blood transplants.
Methods for promoting functional regeneration of mammalian muscle by administering leukaemia inhibitor factor
Patent Number: 6093390This patent teaches that LIF may be used alone, or in combination with neurotrophic factors for the stimulation of neurogenesis and muscle innervation. This patent may be useful for combining with exogenous stem cell sources such as cord blood. Additionally, the patent may be used for treating patients with multiple sclerosis.
Satellite cell proliferation in adult skeletal muscle
Patent Number: 5466676This patent teaches methods of transfecting various stem cells with therapeutic or marker genes. Particularly, muscle stem cells, called satellite cells are discussed as target cells suitable for transfection.
Hepes based basal nutrient medium for the isolation and culturing of stem cells
Patent Number: 6162643This is a composition of matter patent on a tissue culture medium that is useful for the growth of various stem cells.
Process and media for the growth of human epithelia
Patent Number: 5834312This patent covers a liquid composition that is useful for the growth of epithelial cells and various stem cells that differentiate along the epithelial lineages. Relevant types of cells generated by this culture could be corneal epithelial or gingival cells.
Stimulation, production and culturing of hematopoietic progenitor cells by fibroblast growth factors
Patent Number: 5612211This patent covers the expansion of hematopoietic stem cells, both in vitro and in vivo with fibroblast growth factors. This patent is important not only for stimulation of post-ablation hematopoiesis, but can also be used to cover angiogenesis stimulation by fibroblast growth factors since angiogenesis involves hematopoietic stem cells, at least in some embodiments.
Method of stimulating bone marrow regeneration
Patent Number: 5888965This patent teaches how to enhance hematopoiesis using hepatocyte growth factor alone or in combination with other cytokines.
Methods for stimulating hematopoietic progenitors using hepatocyte growth factor and lymphokines
Patent Number: 5362716This patent covers stimulation of hematopoietic stem cells by administration of hepatocyte growth factor with either IL-3 or GM-CSF. Hepatocyte growth factor has been used clinically in a variety of situations including to stimulate angiogenesis. It may be interesting, in light of the claimed pro-hematopoietic stem cell activity of hepatocyte growth factor, to try using this cytokine...
Proliferative action of leukaemia inhibitory factor on satellite cells
Patent Number: 5435999Satellite cells are muscle stem cells. This patent teaches that LIF either alone, or together with TGF-beta, EGF, or FGF, is capable of stimulating proliferation of muscle satellite cells. This technology is useful not only for stimulating proliferation of endogenous satellite cells after...