Class: Expansion (424)
Method for culturing human hematopoietic stem cells in vitro
Patent Number: 5436151This patent teaches how to culture hematopoietic stem cells so as to expand the hematopoietic repopulating ability through the culture on top of stromal cells, however under conditions so that the stromal cells are not in physical contact with the hematopoietic stem cells. There is great interest in methods of culturing and expanding stem cell populations using various types of "feeder...
Hematopoietic stem cell growth-promoting compositions containing a fibroblast-derived fragment of fibronectin and a growth factor, and methods employing them in vitro or in vivo
Patent Number: 5668104This patent covers a protein that expands hematopoietic stem cells called FDF-3.
Conditioned medium useful for sustaining growth of colonic crypt cells
Patent Number: 5316937Colonic crypt cells are a population of self renewing stem cells that are depleted after radiation and in some situations chemotherapy due to their rapid basal proliferation. In this patent a method of stimulating crypt cell proliferation is disclosed through administration of a conditioned media. This patent may be useful for identifying the active ingredient in the conditioned media and...
Medium and matrix for long-term proliferation of cells
Patent Number: 6730315This patent covers a hydrogel mixture that is useful for storage and/or expansion of cells, especially useful for stem cell applications. This technology may be used to form an in vivo depot of stem cells, or may be embedded with stem cell chemoattractants to call in endogenous stem cells into an area of need.
Serum-free basal and culture medium for hematopoietic and leukemia cells
Patent Number: 5397706This patent teaches the making of a serum free media for growth hematopoietic stem cells. Such a media is useful since the addition of fetal serum and especially fetal calf serum in culture medium for cell therapy is associated with regulatory hurdles.
Proliferation of hepatocyte precursors
Patent Number: 6146889Disclosed are culture conditions and compositions of matter that are useful for expansion of liver stem cells. This patent is useful not only for the generation of single cell hepatocytes, but may be used with other scaffold patents in order to generate artificial liver lobes.
Hemopoietic stem cell multiplier
Patent Number: 6221359This patent covers the use of hepatocyte growth factor (and various combinations) for the stimulation of hematopoietic stem cells.
Methods of proliferating undifferentiated neural cells
Patent Number: 7,115,418This patent teaches ways of expanding neural stem cells without inducing loss of replicative ability. Specifically, this involves culture with one or more growth factors selected from a group comprising of EGF, amphiregulin, FGF-1, FGF-2 and TGF-beta.
Growth factor-induced proliferation of neural precursor cells in vivo
Patent Number: 5980885This patent teaches the in vivo expansion of neural stem cells through administration of fibroblast growth factor in combination with an agent selected from the group comprising of: EGF, TGF, and amphiregulin. This patent is useful for the treatment of degenerative nervous system diseases alone, or in combination with exogenously administered stem cells.
In vitro growth and proliferation of multipotent neural stem cells and their progeny
Patent Number: 5851832This patent covers a type of neural stem cell that can differentiate into neurons and neuron supporting cells. This patent also teaches ways of expanding and differentiating the neural stem cells.