Class: Expansion (424)
Ex-vivo expansion of stem cells using combinations of interleukin-3 (IL-3) variants and other cytokines
Patent Number: 5997860This patent covers IL-3 and various deviations of it, in combination with other hematopoietic stem cell stimulatory cytokines for acceleration of hematopoietic recovery after stem cell transplantation. This patent is useful in situations in which the stem cell dose administered may be relatively low, such as cord blood transplants given to adult recipients.
Method for regulating neuron development and maintenance
Patent Number: 7,173,001Leukemia inhibitory factor (LIF) is a member of the IL-6 family of cytokines that was originally identified based on its ability to induce differentiation of myeloid leukemia cells. Its homology ciliary neurotrophic factor (CNTF) has been shown to support the resistance to apoptosis of numerous types of peripheral and central nervous system neurons, as well as induce new neurite formation...
Therapeutic uses of interleukin-3 (IL-3) multiple mutation polypeptides
Patent Number: 6051217This patent provides compositions of matter for various forms of the cytokine IL-3. Uses of IL-3 such as stimulation of hematopoiesis are described. Since myeloid suppressor cells express the IL-3 receptor, it may be interesting to see if IL-3 can actually mediate immune suppressive functions.
Method of enhancing the growth of gut epithelial cells by administration of a cytokine such as interleukin II
Patent Number: 5437863Gut epithelial cells are proliferating, well at least the stem cells that give rise to them, are in a state of constant proliferation. This is one of the reasons why after chemotherapy and/or radiation therapy, there is adverse effects associated with the GI tract. This patent teaches that proliferation of these cells can be stimulated by IL-6, IL-11, LIF, Oncostatin...
Culture of totipotent embryonic inner cells mass cells and production of bovine animals
Patent Number: 6107543This patent is about ways of cloning cows using stem cells harvested form the inner cell mass.
Single chain peptide compounds having hemoregulatory activity
Patent Number: 5629293This is a composition of matter patent on a peptide that has stimulatory activity to stem cells of the hematopoietic system. This patent can be used for not only stimulating hematopoiesis in a patient, but also for other novel uses such as angiogenesis.
Double chain peptide compounds having hemoregulatory activity
Patent Number: 5610141This patent is a composition of matter patent covering a novel peptide that has ability to stimulate bone marrow proliferation and hematopoiesis. This is a very useful patent for pharmaceutical development since there is a need in the art for agents with good pharmacokinetics that stimulate hematopoiesis.
Methods and reagents for lengthening telomeres
Patent Number: 5686306This patent provides compositions of matter, specifically peptide targets for telomerase, which allow for enhanced telomerase activity and longer cellular life span.
Use of c-kit ligand with TNF-.alpha. and hematopoietic factors for the expansion or differentiation of hematopoietic cells
Patent Number: 6159461Combinations of cytokines are provided in this patent for expanding the number of hematopoietic stem cells. Cytokines include stem cell factor, tnf-alpha, and pixy. This is somewhat interesting since TNF alpha is usually considered to inhibit hematopoiesis.
Method for culturing hematopoietic cells
Patent Number: 5460964This patent teaches the culture of hematopoietic stem cells in a manner that the cells do not adhere to the stromal cells that provide various trophic growth factors. IL-3 and MIP-1 alpha are also covered for use in the hematopoietic stem cell culture system described herein.