Class: Expansion (424)
Polypeptide derivatives of human granulocyte colony stimulating factor
Patent Number: 5362853G-CSF is used clinically for stimulation of neutrophil production in pateints that have taken chemotherapy, radiation therapy (in some cases), as well as post bone marrow tranplant. This patent covers peptide derivatives of G-CSF that are useful for stimulation of hematopoiesis. It may be interesting to use this patent to compete with currently used G-CSF formulations.
Tetrapeptide inhibiting the entry into cycle of hemopoietic stem cells processes for its preparation, and its uses
Patent Number: 5114926This invention covers the synthethized form of a tetrapeptide that inhibits bone marrow stem cell entery into cell cycle. The original inhibitory activity was derived from fetal calf bone marrow as a biological "soup" but in this patent synthesis and structure are revealed. The use of agents that inhibit stem cell entry into cell cycle could occur when chemotherapy or radiation is...
Process for replicating bone marrow in vitro and using the same
Patent Number: 4721096This patent is broad reaching in that it covers the ex vivo expansion of bone marrow for treating a pateint whose bone marrow has been comprised. Essentially, this patent was ahead of its time since numerous companies are trying to perform this process even today. Essentially the patent's since independent claim covers extraction of bone marrow, ex vivo replication so that hematopoietic...
Hemolymphopoietic growth factors, process for purifying and producing hemolymphopoietic growth factors and pharmaceutical compositions made therefrom
Patent Number: 5264418This patent claims a hematopoietic stem cell growth factor called HLGF. This factor seems to synergize with other stem cell stimulator factors such as G-CSF, GM-CSF, and IL-3. The modern identify of this factor will be of interest since it may be developed into a therapeutic.
Human pluripotent granulocyte colony-stimulating factor
Patent Number: 5580755This patent covers a growth factor called human pluripotent granulocyte colony stimulating factor. Since names of growth factors have been standardized, it is difficult to tell which modern-day cytokine this is referring to. In any case, this growth factor is an expander of hematopoietic stem cells, and is useful for treatment of patients whose hematopoietic system has been minimized either...
Human pluripotent hematopoietic colony stimulating factor, method of production and use
Patent Number: 6838549This is a patent for a hematopoietic stimulatory cytokine that the inventors named pluripoietin alpha. This cytokine is described in several papers including (Gabrilove et al. Pluripoietin : A Second Human Hematopoietic Colony-Stimulating Factor Produced by the Human Bladder Carcinoma Cell Line 5637, PNAS | April 15, 1986 | vol. 83 | no. 8 | 2478-2482). This...
Human pluripotent hematopoietic colony stimulating factor, method of use
Patent Number: 6419918This patent covers the pluripotent colony stimulating factor, a type of cytokine that is not really described in terms of modern nomenclature in this patent. The use of such stem cell stimulatory cytokines that come from the hematopoietic system should be explored for other types of stem cells...this is especially since there is so much similarity between stem cells of various tissues not...
Human pluripotent hematopoietic colony stimulating factor and cell line producing same
Patent Number: 6114166This patent covers a cytokine that stimulates proliferation of hematopoietic stem cells which give rise to all hematopoietic lineages.
Pharmacological preparations comprising human pluripotent hematopoietic colony stimulating factor
Patent Number: 5670146This patent covers the various formulations of human p-CSF. It also covers the factor's use for stimulation of hematopoiesis. I wonder what the modern name for p-CSF is?
DNA encoding GM-CSF and a method of producing GM-CSF protein
Patent Number: 5908763This patent covers composition of matter for the hematopoietic cytokine granulocyte monocyte colony stimulating factor.