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Patents (1436 Stem Cell Patents)

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Class: Expansion (424)

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Method of using IL-11 for treating deficiencies in hematopoietic progenitor or stem cells

Patent Number: 6066317

This patent teaches that interleukin 11 can be administered into patients for stimulation of hematopoietic activity. Interleukin 11 is known to upregulate platelet production but not as potently as TPO.

Inventors: Yang, Yu-Chung (Indianapolis, IN); Bennett, Frances K. (Melrose, MA); Paul, Stephan R. (Wyncote, PA)

Assignee: Genetics Institute, Inc. (Cambridge, MA)

Date of First Priority Issue: Wednesday November 22nd, 1989

SCL: a hematopoietic growth and differentiation factor

Patent Number: 5214133

This patent is for a transcription factor associated with stem cell activity. The factor is a basic helix-loop-helix transcription factor called SCL/Tal1. It is expressed in cells that possess hematopoietic stem cell activity and controls numerous genes associated with stem cell functions. Modification of activity of this transcription factor may be used...

Inventors: Kirsch, Ilan R. (Potomac, MD); Begley, C. Glenn (North Carlton, AU)

Assignee: The United States of America as represented by the Secretary of the (Washington, DC)

Date of First Priority Issue: Friday November 17th, 1989

Method for increasing hematopoietic progenitor cells by stem cell factor

Patent Number: 6967029

This patent has 2 independent claims both covering the use of stem cell factor for stimulation of hematopoiesis. The first independent claim covers its use in vivo, whereas the second covers its use ex vivo.

Inventors: Zsebo, Krisztina M. (Thousand Oaks, CA); Bosselman, Robert A. (Thousand Oaks, CA); Suggs, Sidney V. (Newbury Parks, CA); Martin, Francis H. (Thousand Oaks, CA)

Assignee: Amgen Inc. (Thousand Oaks, CA)

Date of First Priority Issue: Monday October 16th, 1989

Stem cell factor compositions

Patent Number: 6841147

This is a composition of matter patent on the kit-ligand, otherwise known as stem cell factor. Stem cell factor is involved in regulation of a variety of stem cells in addition to hematopoietic stem cells. This patent is particularly important for when novel methods of inducing stem cell differentation in vivo are discovered and stem cell factor may be added to these methods to either...

Inventors: Zsebo, Krisztina M. (Thousand Oaks, CA); Bosselman, Robert A. (Thousand Oaks, CA); Suggs, Sidney V. (Newbury Park, CA); Martin, Francis H. (Thousand Oaks, CA)

Assignee: Amgen, Inc. (Thousand Oaks, CA)

Date of First Priority Issue: Monday October 16th, 1989

Stem cell factor and compositions

Patent Number: 6207802

This is one of the composition of matter patents on the stem cell stimulatory cytokine called "stem cell factor". Since the receptor for this cytokine, c-kit, is present on numerous other types of stem cells (ie cardiac, muscle, kidney stem cells), it is of interest whether this cytokine can also be of use in expanding non-hematopoietic stem cells.

Inventors: Zsebo, Krisztina M. (Thousand Oaks, CA); Bosselman, Robert A. (Thousand Oaks, CA); Suggs, Sidney V. (Newbury Park, CA); Martin, Francis H. (Thousand Oaks, CA)

Assignee: Amgen Inc. (Thousand Oaks, CA)

Date of First Priority Issue: Monday October 16th, 1989

Stem cell factor

Patent Number: 6204363

This patent covers the composition of matter for a stem cell expansion protein named "stem cell factor", this is the ligand for c-kit.

Inventors: Zsebo, Krisztina M. (Thousand Oaks, CA); Bosselman, Robert A. (Thousand Oaks, CA); Suggs, Sidney V. (Newbury Park, CA); Martin, Francis H. (Thousand Oaks, CA)

Assignee: Amgen Inc. (Thousand Oaks, CA)

Date of First Priority Issue: Monday October 16th, 1989

Method for inhibiting growth of stem cells

Patent Number: 5674841

Disclosed is a peptide that inhibits stem cell proliferation...it doesnt give a name for the peptide..

Inventors: Pragnell, Ian B. (Glasgow, GB6); Donaldson, Debra D. (Cambridge, MA); Graham, Gerald J. (Glasgow, GB6); Wong, Gordon G. (Jamaica Plain, MA)

Assignee: Genetics Institute, Inc. (Cambridge, MA)

Date of First Priority Issue: Monday September 25th, 1989

Method for stimulating production of bone marrow cell growth factors using dithiocarbamates

Patent Number: 5169765

This patent teaches that dithiocarbamate and its analogues have the ability to stimulate bone marrow production of hematopoietic growth factors. Dithiocarbamate may be used according to the invention for stimulation of hematopoietic cells to produce growth factors, and subsequently the dithiocarbamate may be taken off the cells. While this patent seems like a really interesting method of...

Inventors: Borch, Richard F. (Pittsford, NY); Schmalbach, Therese K. (Newton, MA)

Assignee: University of Rochester (Rochester, NY)

Date of First Priority Issue: Tuesday September 12th, 1989

Hemoregulatory peptides

Patent Number: 5620957

This patent provides novel compositions of matter for stimulation of hematopoietic stem cells. This patent is useful for post chemotherapy and post radiation therapy stimulation of blood cell production. It may be useful for stimulation of other stem cells as well, including for stimulation of endothelial precursors and angiogenesis.

Inventors: Bhatnagar, Pradip K. (Exton, PA); Huffman, William F. (Malvern, PA); Talmadge, James E. (Bellevue, NE)

Assignee: SmithKline Beecham Corporation (Philadelphia, PA)

Date of First Priority Issue: Friday July 14th, 1989

Method for protecting bone marrow against chemotherapeutic drugs using transforming growth factor beta 1

Patent Number: 5278145

TGF-beta is an inhibitor of hematopoietic stem cell proliferation. It is known that autologous TGF-b is involved in keeping stem cells in a quiescent G0 state. This patent teaches the systemic administration of TGF-b before administration of a chemotherapeutic drug so as to protect the stem cells from damage.

Inventors: Keller, Jonathan R. (Frederick, MD); Ruscetti, Francis W. (Rockville, MD); Wiltrout, Robert (Frederick, MD)

Assignee: The United States of America as represented by the Department of Health (Washington, DC)

Date of First Priority Issue: Thursday June 29th, 1989

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