Class: Expansion (424)
Methods and compositions for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells
Patent Number: 6326198This patent provides systems for expanding hematopoietic stem cells, but culturing of these cells on stromal cells which secrete IL-6, and/or GM-CSF. It is important for the stromal cells to be secreting these compounds since stromal cells possess a wide variety of hematopoietic stimulatory signals, some known and others unknown. The synergy of the stromal signals with IL-6 and/or GM-CSF is...
Devices for maintaining and growing human stem and/or hematopoietics cells
Patent Number: 5888807This patent provides bioreactors and specialized culture vessels that are useful for the growth and expansion of human hematopoietic stem cells.
Methods and compositions for the ex vivo replication of human hematopoietic stem cells
Patent Number: 5670351This patent covers methods of expanding human hematopoietic stem cells through ex vivo transfection with various genes. Specific culture conditions are also provided. This patent can be used for post myeloablative reconsitution, but also, theoretically, for stimulation of angiogenesis by administration of the bone marrow stem cells into ischemia areas.
Device for maintaining and growing human stem and/or hematopoietics cells
Patent Number: 5459069This patent provides tissue culture devices that can be used for expansion of hematopoietic stem cells. The tissue culture devices allow for a culture of stem cells to be performed so that the stromal cells that provide various factors to the stem cells do not come into direct contact with the stem cells.
Method for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells
Patent Number: 5437994This patent teaches methods of expanding human hematopoietic cells ex vivo using various cytokine cocktails. The patent is heavily cited by other patents and its claims appear to be far-reaching.
Methods and compositions for the optimization of human hematopoietic progenitor cell cultures
Patent Number: 5399493The genetic engineering of hematopoietic stem cells offers the potential to cure several disease, including severe combined immunodeficiency, sickle cell anemia, beta thalessemia, etc. This patent teaches how to ex vivo genetically engineer hematopoietic stem cells through the use of retroviral vectors. This patent is highly cited by other patents.
Maintaining cells for an extended time by entrapment in a contracted matrix
Patent Number: 5981211This patent teaches how to grow cells outside of the body but in chambers that can be connected to an extracorporeal set up. In one particular embodiment this patent may be used for the generation of an artificial liver.
Osteogenic growth polypeptides identified from regenerating bone marrow
Patent Number: 5461034This patent covers a composition of matter (peptide) that is derived from bone marrow, that stimulates bone formation. The peptide may be useful for healing through stimulation of endogenous stem cells, as well as through administration in combination with a stem cell source so as to accelerate bone healing.
Methods, compositions and devices for growing human hematopoietic cells
Patent Number: 5605822This patent teaches culture systems for growing and expanding hematopoietic stem cells. The culture system consists of a gene-transfected stromal layer that produces growth factors, as well as a continuous perfusion system which allows media to pass over the cells.
Bone marrow suppressing agents
Patent Number: 4976950This patent has 2 independent claims, the first covering a method of suppressing the bone marrow, the second covering a sterile injectable capable of suppressing the bone marrow. The method by which this patent teaches to suppress the bone marrow is through administration of a sterile composition containing the radionuclide Yttrium-90 complexed with at least one macrocycle aminophosphonic acid...